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Target
Lysine-specific histone demethylase 1A
Ligand
BDBM439105
Substrate
n/a
Meas. Tech.
FL-LSD1 LC-MS Assay
IC50
28250±n/a nM
Citation
 Du-Cuny, L; Xiao, Q; Xun, G; Zheng, Q Substituted 5-cyanoindole compounds and uses thereof US Patent  US10604502 Publication Date 3/31/2020 
Target
Name:
Lysine-specific histone demethylase 1A
Synonyms:
AOF2 | BRAF35-HDAC complex protein BHC110 | Flavin-containing amine oxidase domain-containing protein 2 | KDM1 | KDM1A | KDM1A_HUMAN | KIAA0601 | LSD1 | Lysine-specific demethylase 1 (LSD1) | Lysine-specific histone demethylase 1 | Lysine-specific histone demethylase 1 (LSD1)
Type:
Enzyme
Mol. Mass.:
92901.01
Organism:
Homo sapiens (Human)
Description:
O60341
Residue:
852
Sequence:
MLSGKKAAAAAAAAAAAATGTEAGPGTAGGSENGSEVAAQPAGLSGPAEVGPGAVGERTPRKKEPPRASPPGGLAEPPGSAGPQAGPTVVPGSATPMETGIAETPEGRRTSRRKRAKVEYREMDESLANLSEDEYYSEEERNAKAEKEKKLPPPPPQAPPEEENESEPEEPSGVEGAAFQSRLPHDRMTSQEAACFPDIISGPQQTQKVFLFIRNRTLQLWLDNPKIQLTFEATLQQLEAPYNSDTVLVHRVHSYLERHGLINFGIYKRIKPLPTKKTGKVIIIGSGVSGLAAARQLQSFGMDVTLLEARDRVGGRVATFRKGNYVADLGAMVVTGLGGNPMAVVSKQVNMELAKIKQKCPLYEANGQAVPKEKDEMVEQEFNRLLEATSYLSHQLDFNVLNNKPVSLGQALEVVIQLQEKHVKDEQIEHWKKIVKTQEELKELLNKMVNLKEKIKELHQQYKEASEVKPPRDITAEFLVKSKHRDLTALCKEYDELAETQGKLEEKLQELEANPPSDVYLSSRDRQILDWHFANLEFANATPLSTLSLKHWDQDDDFEFTGSHLTVRNGYSCVPVALAEGLDIKLNTAVRQVRYTASGCEVIAVNTRSTSQTFIYKCDAVLCTLPLGVLKQQPPAVQFVPPLPEWKTSAVQRMGFGNLNKVVLCFDRVFWDPSVNLFGHVGSTTASRGELFLFWNLYKAPILLALVAGEAAGIMENISDDVIVGRCLAILKGIFGSSAVPQPKETVVSRWRADPWARGSYSYVAAGSSGNDYDLMAQPITPGPSIPGAPQPIPRLFFAGEHTIRNYPATVHGALLSGLREAGRIADQFLGAMYTLPRQATPGVPAQQSPSM
  
Inhibitor
Name:
BDBM439105
Synonyms:
US10604502, Ex # 93
Type:
Small organic molecule
Emp. Form.:
C26H30N4O
Mol. Mass.:
414.5426
SMILES:
Cc1cc2n(cc(-c3cnc4CCC(C)(C)Nc4c3)c2cc1C#N)[C@@H]1CC[C@H](O)CC1 |r,wU:24.27,27.31,(-5.03,-1.87,;-3.7,-1.1,;-2.36,-1.87,;-1.03,-1.1,;.44,-1.58,;1.34,-.33,;.44,.91,;.91,2.38,;-.12,3.52,;.36,4.99,;1.86,5.31,;2.34,6.77,;3.85,7.09,;4.88,5.95,;5.27,7.44,;6.36,6.35,;4.4,4.48,;2.89,4.16,;2.42,2.7,;-1.03,.44,;-2.36,1.21,;-3.7,.44,;-5.03,1.21,;-6.36,1.98,;.91,-3.04,;-.12,-4.19,;.36,-5.65,;1.86,-5.97,;2.34,-7.44,;2.89,-4.83,;2.42,-3.36,)|
Structure:
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