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Target
Lysine-specific histone demethylase 1A
Ligand
BDBM439108
Substrate
n/a
Meas. Tech.
FL-LSD1 LC-MS Assay
IC50
9.00±n/a nM
Citation
 Du-Cuny, L; Xiao, Q; Xun, G; Zheng, Q Substituted 5-cyanoindole compounds and uses thereof US Patent  US10604502 Publication Date 3/31/2020 
Target
Name:
Lysine-specific histone demethylase 1A
Synonyms:
AOF2 | BRAF35-HDAC complex protein BHC110 | Flavin-containing amine oxidase domain-containing protein 2 | KDM1 | KDM1A | KDM1A_HUMAN | KIAA0601 | LSD1 | Lysine-specific demethylase 1 (LSD1) | Lysine-specific histone demethylase 1 | Lysine-specific histone demethylase 1 (LSD1)
Type:
Enzyme
Mol. Mass.:
92901.01
Organism:
Homo sapiens (Human)
Description:
O60341
Residue:
852
Sequence:
MLSGKKAAAAAAAAAAAATGTEAGPGTAGGSENGSEVAAQPAGLSGPAEVGPGAVGERTPRKKEPPRASPPGGLAEPPGSAGPQAGPTVVPGSATPMETGIAETPEGRRTSRRKRAKVEYREMDESLANLSEDEYYSEEERNAKAEKEKKLPPPPPQAPPEEENESEPEEPSGVEGAAFQSRLPHDRMTSQEAACFPDIISGPQQTQKVFLFIRNRTLQLWLDNPKIQLTFEATLQQLEAPYNSDTVLVHRVHSYLERHGLINFGIYKRIKPLPTKKTGKVIIIGSGVSGLAAARQLQSFGMDVTLLEARDRVGGRVATFRKGNYVADLGAMVVTGLGGNPMAVVSKQVNMELAKIKQKCPLYEANGQAVPKEKDEMVEQEFNRLLEATSYLSHQLDFNVLNNKPVSLGQALEVVIQLQEKHVKDEQIEHWKKIVKTQEELKELLNKMVNLKEKIKELHQQYKEASEVKPPRDITAEFLVKSKHRDLTALCKEYDELAETQGKLEEKLQELEANPPSDVYLSSRDRQILDWHFANLEFANATPLSTLSLKHWDQDDDFEFTGSHLTVRNGYSCVPVALAEGLDIKLNTAVRQVRYTASGCEVIAVNTRSTSQTFIYKCDAVLCTLPLGVLKQQPPAVQFVPPLPEWKTSAVQRMGFGNLNKVVLCFDRVFWDPSVNLFGHVGSTTASRGELFLFWNLYKAPILLALVAGEAAGIMENISDDVIVGRCLAILKGIFGSSAVPQPKETVVSRWRADPWARGSYSYVAAGSSGNDYDLMAQPITPGPSIPGAPQPIPRLFFAGEHTIRNYPATVHGALLSGLREAGRIADQFLGAMYTLPRQATPGVPAQQSPSM
  
Inhibitor
Name:
BDBM439108
Synonyms:
US10604502, Ex # 96
Type:
Small organic molecule
Emp. Form.:
C27H29N3O
Mol. Mass.:
411.5387
SMILES:
Cc1cc2n(cc(-c3cccc4NC(C)(C)C=Cc34)c2cc1C#N)[C@@H]1CC[C@H](O)CC1 |r,wU:24.27,27.31,c:16,(-5.32,-.81,;-3.98,-.04,;-2.65,-.81,;-1.32,-.04,;.15,-.51,;1.05,.73,;.15,1.98,;.62,3.44,;-.41,4.59,;.07,6.05,;1.58,6.37,;2.61,5.23,;4.11,5.55,;5.14,4.4,;6.65,4.72,;5.54,5.89,;4.67,2.94,;3.16,2.62,;2.13,3.76,;-1.32,1.5,;-2.65,2.27,;-3.98,1.5,;-5.32,2.27,;-6.65,3.04,;.62,-1.98,;-.41,-3.12,;.07,-4.59,;1.58,-4.91,;2.05,-6.37,;2.61,-3.76,;2.13,-2.3,)|
Structure:
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