Reaction Details Report a problem with these data
Target
Bromodomain-containing protein 4 [352-457]
Ligand
BDBM439584
Substrate
n/a
Meas. Tech.
TR-FRET Assay
Ki
1.40±n/a nM
Citation
 Hasvold, LA; Liu, D; McDaniel, KF; Pratt, J; Sheppard, G; Wang, L Bromodomain inhibitors US Patent  US10633379 Publication Date 4/28/2020 
Target
Name:
Bromodomain-containing protein 4 [352-457]
Synonyms:
BRD4 | BRD4_HUMAN | Bromodomain-containing protein 4 (BRD4) | Bromodomain-containing protein 4 (BRD4)(aa 352-457) | Bromodomain-containing protein 4 (BRD4-BD2) | HUNK1
Type:
Enzyme Catalytic Domain
Mol. Mass.:
12432.37
Organism:
Homo sapiens (Human)
Description:
BDII: amino acid E352-M457
Residue:
106
Sequence:
EQLKCCSGILKEMFAKKHAAYAWPFYKPVDVEALGLHDYCDIIKHPMDMSTIKSKLEAREYRDAQEFGADVRLMFSNCYKYNPPDHEVVAMARKLQDVFEMRFAKM
  
Inhibitor
Name:
BDBM439584
Synonyms:
US10633379, Example 115
Type:
Small organic molecule
Emp. Form.:
C27H28ClN3O5
Mol. Mass.:
509.981
SMILES:
CCNC(=O)c1cc2c(cn(C)c(=O)c2[nH]1)-c1cc(ccc1Oc1c(C)cccc1Cl)C(C)(O)CO
Structure:
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