Reaction Details Report a problem with these data
Target
Ataxin-2
Ligand
BDBM258567
Substrate
n/a
Meas. Tech.
Enzyme Inhibition Assay
IC50
68.5±n/a nM
Citation
 Hunziker, D; Mattei, P; Mauser, H; Prunotto, M; Ullmer, C Diazaspirocycloalkane and azaspirocycloalkane US Patent  US10633384 Publication Date 4/28/2020 
Target
Name:
Ataxin-2
Synonyms:
ATX2 | ATX2_HUMAN | ATXN2 | SCA2 | Spinocerebellar ataxia type 2 protein | TNRC13 | Trinucleotide repeat-containing gene 13 protein
Type:
n/a
Mol. Mass.:
140337.65
Organism:
Homo sapiens (Human)
Description:
Q99700
Residue:
1313
Sequence:
MRSAAAAPRSPAVATESRRFAAARWPGWRSLQRPARRSGRGGGGAAPGPYPSAAPPPPGPGPPPSRQSSPPSASDCFGSNGNGGGAFRPGSRRLLGLGGPPRPFVVLLLPLASPGAPPAAPTRASPLGARASPPRSGVSLARPAPGCPRPACEPVYGPLTMSLKPQQQQQQQQQQQQQQQQQQQQQQQPPPAAANVRKPGGSGLLASPAAAPSPSSSSVSSSSATAPSSVVAATSGGGRPGLGRGRNSNKGLPQSTISFDGIYANMRMVHILTSVVGSKCEVQVKNGGIYEGVFKTYSPKCDLVLDAAHEKSTESSSGPKREEIMESILFKCSDFVVVQFKDMDSSYAKRDAFTDSAISAKVNGEHKEKDLEPWDAGELTANEELEALENDVSNGWDPNDMFRYNEENYGVVSTYDSSLSSYTVPLERDNSEEFLKREARANQLAEEIESSAQYKARVALENDDRSEEEKYTAVQRNSSEREGHSINTRENKYIPPGQRNREVISWGSGRQNSPRMGQPGSGSMPSRSTSHTSDFNPNSGSDQRVVNGGVPWPSPCPSPSSRPPSRYQSGPNSLPPRAATPTRPPSRPPSRPSRPPSHPSAHGSPAPVSTMPKRMSSEGPPRMSPKAQRHPRNHRVSAGRGSISSGLEFVSHNPPSEAATPPVARTSPSGGTWSSVVSGVPRLSPKTHRPRSPRQNSIGNTPSGPVLASPQAGIIPTEAVAMPIPAASPTPASPASNRAVTPSSEAKDSRLQDQRQNSPAGNKENIKPNETSPSFSKAENKGISPVVSEHRKQIDDLKKFKNDFRLQPSSTSESMDQLLNKNREGEKSRDLIKDKIEPSAKDSFIENSSSNCTSGSSKPNSPSISPSILSNTEHKRGPEVTSQGVQTSSPACKQEKDDKEEKKDAAEQVRKSTLNPNAKEFNPRSFSQPKPSTTPTSPRPQAQPSPSMVGHQQPTPVYTQPVCFAPNMMYPVPVSPGVQPLYPIPMTPMPVNQAKTYRAVPNMPQQRQDQHHQSAMMHPASAAGPPIAATPPAYSTQYVAYSPQQFPNQPLVQHVPHYQSQHPHVYSPVIQGNARMMAPPTHAQPGLVSSSATQYGAHEQTHAMYACPKLPYNKETSPSFYFAISTGSLAQQYAHPNATLHPHTPHPQPSATPTGQQQSQHGGSHPAPSPVQHHQHQAAQALHLASPQQQSAIYHAGLAPTPPSMTPASNTQSPQNSFPAAQQTVFTIHPSHVQPAYTNPPHMAHVPQAHVQSGMVPSHPTAHAPMMLMTTQPPGGPQAALAQSALQPIPVSTTAHFPYMTHPSVQAHHQQQL
  
Inhibitor
Name:
BDBM258567
Synonyms:
US10633384, Example 12.29 | US9493486, 12.29
Type:
Small organic molecule
Emp. Form.:
C22H21Cl2N5O3
Mol. Mass.:
474.34
SMILES:
Clc1cc(Cl)cc(COC(=O)NC2CC3(C2)CC(C3)C(=O)Nc2ccc3[nH]nnc3c2)c1 |(-11.1,3.33,;-10.33,2,;-11.1,.67,;-10.33,-.67,;-11.1,-2,;-8.79,-.67,;-8.02,.67,;-6.48,.67,;-5.71,-.67,;-4.17,-.67,;-3.4,.67,;-3.4,-2,;-1.86,-2,;-.77,-3.09,;.32,-2,;-.77,-.91,;1.41,-3.09,;2.5,-2,;1.41,-.91,;4.04,-2,;4.81,-3.33,;4.81,-.67,;6.35,-.67,;7.12,-2,;8.66,-2,;9.43,-.67,;10.94,-.35,;11.1,1.18,;9.69,1.81,;8.66,.67,;7.12,.67,;-8.79,2,)|
Structure:
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