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Target
Programmed cell death 1 ligand 1
Ligand
BDBM440963
Substrate
n/a
Meas. Tech.
Enzyme-Linked Immunosorbent Assay ELISA
IC50
<100±n/a nM
Citation
 Lange, C; Malathong, V; McMurtrie, DJ; Punna, S; Singh, R; Yang, J; Zhang, P Immunomodulator compounds US Patent  US10639284 Publication Date 5/5/2020 
Target
Name:
Programmed cell death 1 ligand 1
Synonyms:
B7 homolog 1 | B7-H1 | B7H1 | B7H1 | CD274 | CD_antigen=CD274 | PD-L1 | PD1L1_HUMAN | PDCD1 ligand 1 | PDCD1L1 | PDCD1LG1 | PDL1 | Programmed cell death 1 ligand 1 | Programmed death ligand 1
Type:
PROTEIN
Mol. Mass.:
33278.49
Organism:
Homo sapiens (Human)
Description:
ChEMBL_109807
Residue:
290
Sequence:
MRIFAVFIFMTYWHLLNAFTVTVPKDLYVVEYGSNMTIECKFPVEKQLDLAALIVYWEMEDKNIIQFVHGEEDLKVQHSSYRQRARLLKDQLSLGNAALQITDVKLQDAGVYRCMISYGGADYKRITVKVNAPYNKINQRILVVDPVTSEHELTCQAEGYPKAEVIWTSSDHQVLSGKTTTTNSKREEKLFNVTSTLRINTTTNEIFYCTFRRLDPEENHTAELVIPELPLAHPPNERTHLVILGAILLCLGVALTFIFRLRKGRMMDVKKCGIQDTNSKKQSDTHLEET
  
Inhibitor
Name:
BDBM440963
Synonyms:
US10639284, Compound 3.132 | US11426364, Compound 3.132
Type:
Small organic molecule
Emp. Form.:
C34H29ClFN3O4
Mol. Mass.:
598.063
SMILES:
OC(=O)[C@@H]1CCN(Cc2cc(Cl)c(O[C@H]3CCc4c3cccc4-c3ccccc3F)cc2OCc2cncc(c2)C#N)C1 |r|
Structure:
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