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Target
Transmembrane protease serine 11D
Ligand
BDBM441774
Substrate
n/a
Meas. Tech.
Proteasome-Activity Inhibitory Assay
IC50
>20000±n/a nM
Citation
 Yang, J; Cen, JJ; Fan, XM Epoxyketone compounds for enzyme inhibition US Patent  US10640533 Publication Date 5/5/2020 
Target
Name:
Transmembrane protease serine 11D
Synonyms:
Airway trypsin-like protease | HAT | TM11D_HUMAN | TMPRSS11D | Transmembrane protease serine 11D catalytic chain | Transmembrane protease serine 11D non-catalytic chain
Type:
PROTEIN
Mol. Mass.:
46272.53
Organism:
Homo sapiens (Human)
Description:
ChEMBL_840134
Residue:
418
Sequence:
MYRPARVTSTSRFLNPYVVCFIVVAGVVILAVTIALLVYFLAFDQKSYFYRSSFQLLNVEYNSQLNSPATQEYRTLSGRIESLITKTFKESNLRNQFIRAHVAKLRQDGSGVRADVVMKFQFTRNNNGASMKSRIESVLRQMLNNSGNLEINPSTEITSLTDQAAANWLINECGAGPDLITLSEQRILGGTEAEEGSWPWQVSLRLNNAHHCGGSLINNMWILTAAHCFRSNSNPRDWIATSGISTTFPKLRMRVRNILIHNNYKSATHENDIALVRLENSVTFTKDIHSVCLPAATQNIPPGSTAYVTGWGAQEYAGHTVPELRQGQVRIISNDVCNAPHSYNGAILSGMLCAGVPQGGVDACQGDSGGPLVQEDSRRLWFIVGIVSWGDQCGLPDKPGVYTRVTAYLDWIRQQTGI
  
Inhibitor
Name:
BDBM441774
Synonyms:
US10640533, Identification number CX13-104 | US10640533, Table 1.21
Type:
Small organic molecule
Emp. Form.:
C36H46N6O7
Mol. Mass.:
674.7864
SMILES:
CC(C)C[C@H](NC(=O)[C@H](CCc1ccccc1)NC(=O)c1cc(CN2CCOCC2)on1)C(=O)N[C@@H](Cc1ccncc1)C(=O)[C@@]1(C)CO1 |r|
Structure:
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