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Target
Proteasome subunit beta type-1
Ligand
BDBM441781
Substrate
n/a
Meas. Tech.
Proteasome-Activity Inhibitory Assay
IC50
>20000±n/a nM
Citation
 Yang, J; Cen, JJ; Fan, XM Epoxyketone compounds for enzyme inhibition US Patent  US10640533 Publication Date 5/5/2020 
Target
Name:
Proteasome subunit beta type-1
Synonyms:
PSB1_HUMAN | PSC5 | PSMB1 | Proteasome component C5 | Proteasome subunit beta type-1/beta type-5
Type:
PROTEIN
Mol. Mass.:
26493.62
Organism:
Homo sapiens (Human)
Description:
ChEMBL_1366691
Residue:
241
Sequence:
MLSSTAMYSAPGRDLGMEPHRAAGPLQLRFSPYVFNGGTILAIAGEDFAIVASDTRLSEGFSIHTRDSPKCYKLTDKTVIGCSGFHGDCLTLTKIIEARLKMYKHSNNKAMTTGAIAAMLSTILYSRRFFPYYVYNIIGGLDEEGKGAVYSFDPVGSYQRDSFKAGGSASAMLQPLLDNQVGFKNMQNVEHVPLSLDRAMRLVKDVFISAAERDVYTGDALRICIVTKEGIREETVSLRKD
  
Inhibitor
Name:
BDBM441781
Synonyms:
US10640533, Identification number CX13-137 | US10640533, Table 1.28
Type:
Small organic molecule
Emp. Form.:
C32H39N5O5S
Mol. Mass.:
605.748
SMILES:
CC(C)C[C@H](NC(=O)[C@H](Cc1ccncc1)NC(=O)[C@H](CCc1ccccc1)NC(=O)c1cnc(C)s1)C(=O)[C@@]1(C)CO1 |r|
Structure:
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