Reaction Details Report a problem with these data
Target
C-X-C chemokine receptor type 2
Ligand
BDBM385547
Substrate
n/a
Meas. Tech.
In Vitro Affinity Assay
IC50
>200±n/a nM
Citation
 Musicki, B; Bhurruth-Alcor, Y Chemokine CXCR1 and CXCR2 receptor antagonist compounds, and use thereof in the treatment of chemokine-mediated pathologies US Patent  US10647706 Publication Date 5/12/2020 
Target
Name:
C-X-C chemokine receptor type 2
Synonyms:
C-X-C chemokine receptor type 2 (CXCR-2) | C-X-C chemokine receptor type 2 (CXCR2) | CD_antigen=CD182 | CDw128b | CXCR-2 | CXCR2 | CXCR2_HUMAN | Chemokine receptor type 2 (CXCR2) | GRO/MGSA receptor | High affinity interleukin-8 receptor B | IL-8 receptor type 2 | IL-8R B | IL8RB | Interleukin-8 receptor B
Type:
Protein
Mol. Mass.:
40767.88
Organism:
Homo sapiens (Human)
Description:
P25025
Residue:
360
Sequence:
MEDFNMESDSFEDFWKGEDLSNYSYSSTLPPFLLDAAPCEPESLEINKYFVVIIYALVFLLSLLGNSLVMLVILYSRVGRSVTDVYLLNLALADLLFALTLPIWAASKVNGWIFGTFLCKVVSLLKEVNFYSGILLLACISVDRYLAIVHATRTLTQKRYLVKFICLSIWGLSLLLALPVLLFRRTVYSSNVSPACYEDMGNNTANWRMLLRILPQSFGFIVPLLIMLFCYGFTLRTLFKAHMGQKHRAMRVIFAVVLIFLLCWLPYNLVLLADTLMRTQVIQETCERRNHIDRALDATEILGILHSCLNPLIYAFIGQKFRHGLLKILAIHGLISKDSLPKDSRPSFVGSSSGHTSTTL
  
Inhibitor
Name:
BDBM385547
Synonyms:
US10287278, Example 9 | US10647706, Example 9
Type:
Small organic molecule
Emp. Form.:
C23H29ClN4O5S
Mol. Mass.:
509.018
SMILES:
CC[C@@H](Nc1c(Nc2ccc(Cl)c(c2O)S(C)(=O)=NCCN(C)C)c(=O)c1=O)c1ccc(C)o1 |r|
Structure:
Search PDB for entries with ligand similarity: