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Target
Non-receptor tyrosine-protein kinase TYK2 [556-888]
Ligand
BDBM442089
Substrate
n/a
Meas. Tech.
Binding Assay
Kd
0.75±n/a nM
Citation
 Greenwood, JR; Leit de Moradei, SM; Masse, CE; McLean, TH; Mondal, S TYK2 inhibitors and uses thereof US Patent  US10647713 Publication Date 5/12/2020 
Target
Name:
Non-receptor tyrosine-protein kinase TYK2 [556-888]
Synonyms:
Non-receptor tyrosine-protein kinase TYK2 (G556-D888) | Non-receptor tyrosine-protein kinase TYK2 (aa 556-888) | TYK2 | TYK2 JH2 Domain (aa 556-888) | TYK2_HUMAN
Type:
Protein
Mol. Mass.:
36941.98
Organism:
Homo sapiens (Human)
Description:
P29597 (aa 556-888)
Residue:
333
Sequence:
GETSNLIIMRGARASPRTLNLSQLSFHRVDQKEITQLSHLGQGTRTNVYEGRLRVEGSGDPEEGKMDDEDPLVPGRDRGQELRVVLKVLDPSHHDIALAFYETASLMSQVSHTHLAFVHGVCVRGPENIMVTEYVEHGPLDVWLRRERGHVPMAWKMVVAQQLASALSYLENKNLVHGNVCGRNILLARLGLAEGTSPFIKLSDPGVGLGALSREERVERIPWLAPECLPGGANSLSTAMDKWGFGATLLEICFDGEAPLQSRSPSEKEHFYQRQHRLPEPSCPQLATLTSQCLTYEPTQRPSFRTILRDLTRLQPHNLADVLTVNPDSPASD
  
Inhibitor
Name:
BDBM442089
Synonyms:
US10647713, Compound I-33 | US11396508, Compound I-33
Type:
Small organic molecule
Emp. Form.:
C25H21F2N9O
Mol. Mass.:
501.4907
SMILES:
COc1c(Nc2cc(Nc3cc(C)cc(n3)C#N)nc3[nH]c(nc23)C(F)F)cccc1-c1ccn(C)n1
Structure:
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