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Target
Non-receptor tyrosine-protein kinase TYK2 [556-888]
Ligand
BDBM442247
Substrate
n/a
Meas. Tech.
Binding Assay
Kd
5.5±n/a nM
Citation
 Greenwood, JR; Leit de Moradei, SM; Masse, CE; McLean, TH; Mondal, S TYK2 inhibitors and uses thereof US Patent  US10647713 Publication Date 5/12/2020 
Target
Name:
Non-receptor tyrosine-protein kinase TYK2 [556-888]
Synonyms:
Non-receptor tyrosine-protein kinase TYK2 (G556-D888) | Non-receptor tyrosine-protein kinase TYK2 (aa 556-888) | TYK2 | TYK2 JH2 Domain (aa 556-888) | TYK2_HUMAN
Type:
Protein
Mol. Mass.:
36941.98
Organism:
Homo sapiens (Human)
Description:
P29597 (aa 556-888)
Residue:
333
Sequence:
GETSNLIIMRGARASPRTLNLSQLSFHRVDQKEITQLSHLGQGTRTNVYEGRLRVEGSGDPEEGKMDDEDPLVPGRDRGQELRVVLKVLDPSHHDIALAFYETASLMSQVSHTHLAFVHGVCVRGPENIMVTEYVEHGPLDVWLRRERGHVPMAWKMVVAQQLASALSYLENKNLVHGNVCGRNILLARLGLAEGTSPFIKLSDPGVGLGALSREERVERIPWLAPECLPGGANSLSTAMDKWGFGATLLEICFDGEAPLQSRSPSEKEHFYQRQHRLPEPSCPQLATLTSQCLTYEPTQRPSFRTILRDLTRLQPHNLADVLTVNPDSPASD
  
Inhibitor
Name:
BDBM442247
Synonyms:
US10647713, Compound I-208 | US11396508, Compound I-208
Type:
Small organic molecule
Emp. Form.:
C23H25FN8O3S
Mol. Mass.:
512.56
SMILES:
CN(c1cc(ccc1Nc1cc(NC(=O)[C@@H]2C[C@@H]2F)nc2[nH]c(C)nc12)-c1cncn1C)S(C)(=O)=O |r|
Structure:
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