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TargetGlycogen synthase kinase-3 beta
LigandBDBM442933
Substrate/Competitorn/a
Meas. Tech.Kinase Assay
EC50 4.00±n/a nM
Citation Kc, SKMak, CCHofilena, BJMittapalli, GKEastman, BWCao, JBollu, VChiruta, C 6-(6-membered heteroaryl and aryl)isoquinolin-3-yl carboxamides and preparation and use thereof US Patent US10653688 Publication Date 5/19/2020
More Info.:Get all data from this article,  Assay Method
 
Glycogen synthase kinase-3 beta
Name:Glycogen synthase kinase-3 beta
Synonyms:GSK-3 beta | GSK-3, beta | Glycogen synthase kinase 3 beta (GSK3B) | Glycogen synthase kinase 3-beta (GSK3B) | Glycogen synthase kinase-3 beta (GSK-3B) | Glycogen synthase kinase-3 beta (GSK3 Beta) | Glycogen synthase kinase-3 beta (GSK3B) | Glycogen synthase kinase-3B (GSK-3B) | Glycogen synthase kinase-3beta (GSK3B) | Serine/threonine-protein kinase GSK3B
Type:Enzyme
Mol. Mass.:46756.38
Organism:Homo sapiens (Human)
Description:P49841
Residue:420
Sequence:
MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTK
VIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSG
EKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHR
DIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDV
WSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHP
WTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALF
NFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST
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  Blast E-value cutoff:
BDBM442933
NameBDBM442933
Synonyms:US10653688, Compound 111
TypeSmall organic molecule
Emp. Form.C22H23FN6O
Mol. Mass.406.456
SMILESF[C@H]1CNCCC1Nc1cncc(n1)-c1ccc2cnc(NC(=O)C3CC3)cc2c1 |r|
Structure
n/a