Target
Estrogen receptor [Y537S]
Ligand
BDBM443442
Substrate
n/a
Meas. Tech.
Competition Binding Assay
Ki
66.9±n/a nM
Citation
 Bastian, JACohen, JDRubio, ASall, DJ Selective estrogen receptor degraders US Patent  US10654866 Publication Date 5/19/2020 
Target
Name:
Estrogen receptor [Y537S]
Synonyms:
ESR | ESR1 | ESR1_HUMAN | Estrogen receptor (Y537S) | Estrogen receptor alpha Y537S | NR3A1
Type:
Enzyme Catalytic Domain
Mol. Mass.:
66154.35
Organism:
Homo sapiens (Human)
Description:
P03372[Y537S]
Residue:
595
Sequence:
MTMTLHTKASGMALLHQIQGNELEPLNRPQLKIPLERPLGEVYLDSSKPAVYNYPEGAAYEFNAAAAANAQVYGQTGLPYGPGSEAAAFGSNGLGGFPPLNSVSPSPLMLLHPPPQLSPFLQPHGQQVPYYLENEPSGYTVREAGPPAFYRPNSDNRRQGGRERLASTNDKGSMAMESAKETRYCAVCNDYASGYHYGVWSCEGCKAFFKRSIQGHNDYMCPATNQCTIDKNRRKSCQACRLRKCYEVGMMKGGIRKDRRGGRMLKHKRQRDDGEGRGEVGSAGDMRAANLWPSPLMIKRSKKNSLALSLTADQMVSALLDAEPPILYSEYDPTRPFSEASMMGLLTNLADRELVHMINWAKRVPGFVDLTLHDQVHLLECAWLEILMIGLVWRSMEHPGKLLFAPNLLLDRNQGKCVEGMVEIFDMLLATSSRFRMMNLQGEEFVCLKSIILLNSGVYTFLSSTLKSLEEKDHIHRVLDKITDTLIHLMAKAGLTLQQQHQRLAQLLLILSHIRHMSNKGMEHLYSMKCKNVVPLSDLLLEMLDAHRLHAPTSRGGASVEETDQSHLATAGSTSSHSLQKYYITGEAEGFPATV
  
Inhibitor
Name:
BDBM443442
Synonyms:
US10654866, Example 8A | US11117902, Example 8A | US11634426, Example 8B
Type:
Small organic molecule
Emp. Form.:
C29H27FN2O3
Mol. Mass.:
470.5347
SMILES:
Cc1cccc-2c1O[C@@H](c1ccc(OCCN3CC(CF)C3)cc1)c1c-2cnc2cc(O)ccc12 |r|
Structure:
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