Reaction Details Report a problem with these data
Target
Mucosa-associated lymphoid tissue lymphoma translocation protein 1
Ligand
BDBM444411
Substrate
n/a
Meas. Tech.
Inhibition of Protease Activity Assay
IC50
1068±n/a nM
Citation
 Numajiri, Y; Okimura, K; Matsumura, Y; Asaba, K; Masuda, T; Tokumaru, K; Goto, Y; Fujii, S Guanidine derivative and medical use thereof US Patent  US10662156 Publication Date 5/26/2020 
Target
Name:
Mucosa-associated lymphoid tissue lymphoma translocation protein 1
Synonyms:
MALT lymphoma-associated translocation | MALT lymphoma-associated translocation (MALT1) | MALT1 | MALT1_HUMAN | MLT | Mucosa-associated lymphoid tissue lymphoma translocation protein 1 | Paracaspase
Type:
Enzyme
Mol. Mass.:
92257.81
Organism:
Homo sapiens (Human)
Description:
Q9UDY8
Residue:
824
Sequence:
MSLLGDPLQALPPSAAPTGPLLAPPAGATLNRLREPLLRRLSELLDQAPEGRGWRRLAELAGSRGRLRLSCLDLEQCSLKVLEPEGSPSLCLLKLMGEKGCTVTELSDFLQAMEHTEVLQLLSPPGIKITVNPESKAVLAGQFVKLCCRATGHPFVQYQWFKMNKEIPNGNTSELIFNAVHVKDAGFYVCRVNNNFTFEFSQWSQLDVCDIPESFQRSVDGVSESKLQICVEPTSQKLMPGSTLVLQCVAVGSPIPHYQWFKNELPLTHETKKLYMVPYVDLEHQGTYWCHVYNDRDSQDSKKVEIIIGRTDEAVECTEDELNNLGHPDNKEQTTDQPLAKDKVALLIGNMNYREHPKLKAPLVDVYELTNLLRQLDFKVVSLLDLTEYEMRNAVDEFLLLLDKGVYGLLYYAGHGYENFGNSFMVPVDAPNPYRSENCLCVQNILKLMQEKETGLNVFLLDMCRKRNDYDDTIPILDALKVTANIVFGYATCQGAEAFEIQHSGLANGIFMKFLKDRLLEDKKITVLLDEVAEDMGKCHLTKGKQALEIRSSLSEKRALTDPIQGTEYSAESLVRNLQWAKAHELPESMCLKFDCGVQIQLGFAAEFSNVMIIYTSIVYKPPEIIMCDAYVTDFPLDLDIDPKDANKGTPEETGSYLVSKDLPKHCLYTRLSSLQKLKEHLVFTVCLSYQYSGLEDTVEDKQEVNVGKPLIAKLDMHRGLGRKTCFQTCLMSNGPYQSSAATSGGAGHYHSLQDPFHGVYHSHPGNPSNVTPADSCHCSRTPDAFISSFAHHASCHFSRSNVPVETTDEIPFSFSDRLRISEK
  
Inhibitor
Name:
BDBM444411
Synonyms:
N-(amino(((5-phenyl-6-(4-(trifluoromethyl)phenyl)pyridin-3-yl)methyl)amino)methylene)benzenesulfonamide | US10662156, Compound of Example 93
Type:
Small organic molecule
Emp. Form.:
C26H21F3N4O2S
Mol. Mass.:
510.531
SMILES:
N\C(NCc1cnc(-c2ccc(cc2)C(F)(F)F)c(c1)-c1ccccc1)=N/S(=O)(=O)c1ccccc1
Structure:
Search PDB for entries with ligand similarity: