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Target
Cyclin-dependent kinase 6
Ligand
BDBM444620
Substrate
n/a
Meas. Tech.
LANCE Ultra ULight Assay
IC50
1.11±n/a nM
Citation
 Xia, G; Wang, Q; Shi, C; Zhai, X; Ge, H; Liao, X; Mao, Y; Xiang, Z; Han, Y; Huo, G; Liu, Y Substituted pyrimidines as cyclin-dependent kinase inhibitors US Patent  US10662186 Publication Date 5/26/2020 
Target
Name:
Cyclin-dependent kinase 6
Synonyms:
CDK6 | CDK6_HUMAN | CDKN6 | Cell division protein kinase 6 | Cyclin-dependent kinase 6 (CDK 6) | Serine/threonine-protein kinase PLSTIRE
Type:
Enzyme Subunit
Mol. Mass.:
36937.42
Organism:
Homo sapiens (Human)
Description:
Q00534
Residue:
326
Sequence:
MEKDGLCRADQQYECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIREVAVLRHLETFEHPNVVRLFDVCTVSRTDRETKLTLVFEHVDQDLTTYLDKVPEPGVPTETIKDMMFQLLRGLDFLHSHRVVHRDLKPQNILVTSSGQIKLADFGLARIYSFQMALTSVVVTLWYRAPEVLLQSSYATPVDLWSVGCIFAEMFRRKPLFRGSSDVDQLGKILDVIGLPGEEDWPRDVALPRQAFHSKSAQPIEKFVTDIDELGKDLLLKCLTFNPAKRISAYSALSHPYFQDLERCKENLDSHLPPSQNTSELNTA
  
Inhibitor
Name:
BDBM444620
Synonyms:
US10662186, Compound 202 | US10988476, Compound I-202
Type:
Small organic molecule
Emp. Form.:
C26H30F2N8
Mol. Mass.:
492.5668
SMILES:
Cc1nc2c(F)cc(cc2n1C(C)(C)C)-c1nc(Nc2ccc3CN(CCN)CCc3n2)ncc1F
Structure:
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