Reaction Details Report a problem with these data
Target
Calcium release-activated calcium channel protein 1
Ligand
BDBM141433
Substrate
n/a
Meas. Tech.
In-Vitro CRAC Channel Inhibition Assay in Jurkat Cells
IC50
159±n/a nM
Citation
 Muthuppalaniappan, M; Viswanadha, S; Merikapudi, GS; Vakkalanka, SK Modulators of calcium release-activated calcium channel US Patent  US10668051 Publication Date 6/2/2020 
Target
Name:
Calcium release-activated calcium channel protein 1
Synonyms:
CRACM1 | CRCM1_HUMAN | Calcium channel (VER) | Calcium release-activated calcium channel | Calcium release-activated calcium channel protein 1 | ORAI1 | Protein orai-1 | TMEM142A | Transmembrane protein 142A
Type:
Protein
Mol. Mass.:
32676.63
Organism:
Homo sapiens (Human)
Description:
Q96D31
Residue:
301
Sequence:
MHPEPAPPPSRSSPELPPSGGSTTSGSRRSRRRSGDGEPPGAPPPPPSAVTYPDWIGQSYSEVMSLNEHSMQALSWRKLYLSRAKLKASSRTSALLSGFAMVAMVEVQLDADHDYPPGLLIAFSACTTVLVAVHLFALMISTCILPNIEAVSNVHNLNSVKESPHERMHRHIELAWAFSTVIGTLLFLAEVVLLCWVKFLPLKKQPGQPRPTSKPPASGAAANVSTSGITPGQAAAIASTTIMVPFGLIFIVFAVHFYRSLVSHKTDRQFQELNELAEFARLQDQLDHRGDHPLTPGSHYA
  
Inhibitor
Name:
BDBM141433
Synonyms:
US10668051, Compound Example 92 | US8921364, 92
Type:
Small organic molecule
Emp. Form.:
C19H12Cl2F4N4O
Mol. Mass.:
459.224
SMILES:
Fc1cc(NC(=O)c2c(Cl)cncc2Cl)ccc1-n1nc(cc1C1CC1)C(F)(F)F
Structure:
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