Reaction Details Report a problem with these data
Target
Calcium release-activated calcium channel protein 1
Ligand
BDBM141440
Substrate
n/a
Meas. Tech.
In-Vitro CRAC Channel Inhibition Assay in Jurkat Cells
IC50
70.3±n/a nM
Citation
 Muthuppalaniappan, M; Viswanadha, S; Merikapudi, GS; Vakkalanka, SK Modulators of calcium release-activated calcium channel US Patent  US10668051 Publication Date 6/2/2020 
Target
Name:
Calcium release-activated calcium channel protein 1
Synonyms:
CRACM1 | CRCM1_HUMAN | Calcium channel (VER) | Calcium release-activated calcium channel | Calcium release-activated calcium channel protein 1 | ORAI1 | Protein orai-1 | TMEM142A | Transmembrane protein 142A
Type:
Protein
Mol. Mass.:
32676.63
Organism:
Homo sapiens (Human)
Description:
Q96D31
Residue:
301
Sequence:
MHPEPAPPPSRSSPELPPSGGSTTSGSRRSRRRSGDGEPPGAPPPPPSAVTYPDWIGQSYSEVMSLNEHSMQALSWRKLYLSRAKLKASSRTSALLSGFAMVAMVEVQLDADHDYPPGLLIAFSACTTVLVAVHLFALMISTCILPNIEAVSNVHNLNSVKESPHERMHRHIELAWAFSTVIGTLLFLAEVVLLCWVKFLPLKKQPGQPRPTSKPPASGAAANVSTSGITPGQAAAIASTTIMVPFGLIFIVFAVHFYRSLVSHKTDRQFQELNELAEFARLQDQLDHRGDHPLTPGSHYA
  
Inhibitor
Name:
BDBM141440
Synonyms:
US10668051, Compound Example 107 | US8921364, 107
Type:
Small organic molecule
Emp. Form.:
C19H13F5N4O
Mol. Mass.:
408.3247
SMILES:
Fc1cccc(C(=O)Nc2ccc(nc2)-n2nc(cc2C2CC2)C(F)(F)F)c1F
Structure:
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