Reaction Details Report a problem with these data
Target
Calcium release-activated calcium channel protein 1
Ligand
BDBM141442
Substrate
n/a
Meas. Tech.
In-Vitro CRAC Channel Inhibition Assay in Jurkat Cells
IC50
47.2±n/a nM
Citation
 Muthuppalaniappan, M; Viswanadha, S; Merikapudi, GS; Vakkalanka, SK Modulators of calcium release-activated calcium channel US Patent  US10668051 Publication Date 6/2/2020 
Target
Name:
Calcium release-activated calcium channel protein 1
Synonyms:
CRACM1 | CRCM1_HUMAN | Calcium channel (VER) | Calcium release-activated calcium channel | Calcium release-activated calcium channel protein 1 | ORAI1 | Protein orai-1 | TMEM142A | Transmembrane protein 142A
Type:
Protein
Mol. Mass.:
32676.63
Organism:
Homo sapiens (Human)
Description:
Q96D31
Residue:
301
Sequence:
MHPEPAPPPSRSSPELPPSGGSTTSGSRRSRRRSGDGEPPGAPPPPPSAVTYPDWIGQSYSEVMSLNEHSMQALSWRKLYLSRAKLKASSRTSALLSGFAMVAMVEVQLDADHDYPPGLLIAFSACTTVLVAVHLFALMISTCILPNIEAVSNVHNLNSVKESPHERMHRHIELAWAFSTVIGTLLFLAEVVLLCWVKFLPLKKQPGQPRPTSKPPASGAAANVSTSGITPGQAAAIASTTIMVPFGLIFIVFAVHFYRSLVSHKTDRQFQELNELAEFARLQDQLDHRGDHPLTPGSHYA
  
Inhibitor
Name:
BDBM141442
Synonyms:
US10668051, Compound Example 111 | US8921364, 111
Type:
Small organic molecule
Emp. Form.:
C18H14F3N5O
Mol. Mass.:
373.3319
SMILES:
FC(F)(F)c1cc(C2CC2)n(n1)-c1ccc(NC(=O)c2cccnc2)cn1
Structure:
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