Reaction Details Report a problem with these data
Target
Ubiquitin carboxyl-terminal hydrolase isozyme L1
Ligand
BDBM445101
Substrate
n/a
Meas. Tech.
UCHL1 Biochemical IC50 Assay
IC50
5500±n/a nM
Citation
 Kemp, M; Stockley, M; Jones, A Cyanopyrrolidines as dub inhibitors for the treatment of cancer US Patent  US10669234 Publication Date 6/2/2020 
Target
Name:
Ubiquitin carboxyl-terminal hydrolase isozyme L1
Synonyms:
Neuron cytoplasmic protein 9.5 | PGP 9.5 | PGP9.5 | UCH-L1 | UCHL1 | UCHL1_HUMAN | Ubiquitin thioesterase L1
Type:
PROTEIN
Mol. Mass.:
24819.03
Organism:
Homo sapiens (Human)
Description:
ChEMBL_974327
Residue:
223
Sequence:
MQLKPMEINPEMLNKVLSRLGVAGQWRFVDVLGLEEESLGSVPAPACALLLLFPLTAQHENFRKKQIEELKGQEVSPKVYFMKQTIGNSCGTIGLIHAVANNQDKLGFEDGSVLKQFLSETEKMSPEDRAKCFEKNEAIQAAHDAVAQEGQCRVDDKVNFHFILFNNVDGHLYELDGRMPFPVNHGASSEDTLLKDAAKVCREFTEREQGEVRFSAVALCKAA
  
Inhibitor
Name:
BDBM445101
Synonyms:
(S)-2-(4-(5-methylisoxazol-4- yl)indoline-1-carbonyl)pyrrolidine- 1-carbonitrile | US10669234, Example 40 | US11319287, Example 40
Type:
Small organic molecule
Emp. Form.:
C18H18N4O2
Mol. Mass.:
322.3611
SMILES:
Cc1oncc1-c1cccc2N(CCc12)C(=O)[C@@H]1CCCN1C#N
Structure:
Search PDB for entries with ligand similarity: