Reaction Details Report a problem with these data
Target
Ubiquitin carboxyl-terminal hydrolase isozyme L1
Ligand
BDBM445152
Substrate
n/a
Meas. Tech.
UCHL1 Biochemical IC50 Assay
IC50
5500±n/a nM
Citation
 Kemp, M; Stockley, M; Jones, A Cyanopyrrolidines as dub inhibitors for the treatment of cancer US Patent  US10669234 Publication Date 6/2/2020 
Target
Name:
Ubiquitin carboxyl-terminal hydrolase isozyme L1
Synonyms:
Neuron cytoplasmic protein 9.5 | PGP 9.5 | PGP9.5 | UCH-L1 | UCHL1 | UCHL1_HUMAN | Ubiquitin thioesterase L1
Type:
PROTEIN
Mol. Mass.:
24819.03
Organism:
Homo sapiens (Human)
Description:
ChEMBL_974327
Residue:
223
Sequence:
MQLKPMEINPEMLNKVLSRLGVAGQWRFVDVLGLEEESLGSVPAPACALLLLFPLTAQHENFRKKQIEELKGQEVSPKVYFMKQTIGNSCGTIGLIHAVANNQDKLGFEDGSVLKQFLSETEKMSPEDRAKCFEKNEAIQAAHDAVAQEGQCRVDDKVNFHFILFNNVDGHLYELDGRMPFPVNHGASSEDTLLKDAAKVCREFTEREQGEVRFSAVALCKAA
  
Inhibitor
Name:
BDBM445152
Synonyms:
4-(2-chlorophenyl)-1- (cyano-L-prolyl)-N- methylindoline-6- carboxamide | US10669234, Example 103 | US11319287, Example 103
Type:
Small organic molecule
Emp. Form.:
C22H21ClN4O2
Mol. Mass.:
408.881
SMILES:
CNC(=O)c1cc2N(CCc2c(c1)-c1ccccc1Cl)C(=O)[C@@H]1CCCN1C#N
Structure:
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