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Target
Ubiquitin carboxyl-terminal hydrolase isozyme L1
Ligand
BDBM445165
Substrate
n/a
Meas. Tech.
UCHL1 Biochemical IC50 Assay
IC50
550±n/a nM
Citation
 Kemp, M; Stockley, M; Jones, A Cyanopyrrolidines as dub inhibitors for the treatment of cancer US Patent  US10669234 Publication Date 6/2/2020 
Target
Name:
Ubiquitin carboxyl-terminal hydrolase isozyme L1
Synonyms:
Neuron cytoplasmic protein 9.5 | PGP 9.5 | PGP9.5 | UCH-L1 | UCHL1 | UCHL1_HUMAN | Ubiquitin thioesterase L1
Type:
PROTEIN
Mol. Mass.:
24819.03
Organism:
Homo sapiens (Human)
Description:
ChEMBL_974327
Residue:
223
Sequence:
MQLKPMEINPEMLNKVLSRLGVAGQWRFVDVLGLEEESLGSVPAPACALLLLFPLTAQHENFRKKQIEELKGQEVSPKVYFMKQTIGNSCGTIGLIHAVANNQDKLGFEDGSVLKQFLSETEKMSPEDRAKCFEKNEAIQAAHDAVAQEGQCRVDDKVNFHFILFNNVDGHLYELDGRMPFPVNHGASSEDTLLKDAAKVCREFTEREQGEVRFSAVALCKAA
  
Inhibitor
Name:
BDBM445165
Synonyms:
(S)-2-(4-(1H-pyrazolo[3,4- b]pyridin-3-yl)indoline-1- carbonyl)pyrrolidine-1- carbonitrile | US10669234, Example 122 | US11319287, Example 122
Type:
Small organic molecule
Emp. Form.:
C20H18N6O
Mol. Mass.:
358.3965
SMILES:
O=C([C@@H]1CCCN1C#N)N1CCc2c1cccc2-c1n[nH]c2ncccc12
Structure:
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