Target
Ubiquitin carboxyl-terminal hydrolase 30
Ligand
BDBM445179
Substrate
n/a
Meas. Tech.
USP30 Biochemical IC50 Assay
IC50
5500±n/a nM
Citation
 Kemp, MStockley, MJones, A Cyanopyrrolidines as dub inhibitors for the treatment of cancer US Patent  US10669234 Publication Date 6/2/2020 
Target
Name:
Ubiquitin carboxyl-terminal hydrolase 30
Synonyms:
Deubiquitinating enzyme 30 | UBP30_HUMAN | USP30 | Ub-specific protease 30 | Ubiquitin carboxyl-terminal hydrolase 30 (USP30) | Ubiquitin thioesterase 30 | Ubiquitin-specific-processing protease 30
Type:
Protein
Mol. Mass.:
58522.90
Organism:
Homo sapiens (Human)
Description:
Q70CQ3
Residue:
517
Sequence:
MLSSRAEAAMTAADRAIQRFLRTGAAVRYKVMKNWGVIGGIAAALAAGIYVIWGPITERKKRRKGLVPGLVNLGNTCFMNSLLQGLSACPAFIRWLEEFTSQYSRDQKEPPSHQYLSLTLLHLLKALSCQEVTDDEVLDASCLLDVLRMYRWQISSFEEQDAHELFHVITSSLEDERDRQPRVTHLFDVHSLEQQSEITPKQITCRTRGSPHPTSNHWKSQHPFHGRLTSNMVCKHCEHQSPVRFDTFDSLSLSIPAATWGHPLTLDHCLHHFISSESVRDVVCDNCTKIEAKGTLNGEKVEHQRTTFVKQLKLGKLPQCLCIHLQRLSWSSHGTPLKRHEHVQFNEFLMMDIYKYHLLGHKPSQHNPKLNKNPGPTLELQDGPGAPTPVLNQPGAPKTQIFMNGACSPSLLPTLSAPMPFPLPVVPDYSSSTYLFRLMAVVVHHGDMHSGHFVTYRRSPPSARNPLSTSNQWLWVSDDTVRKASLQEVLSSSAYLLFYERVLSRMQHQSQECKSEE
  
Inhibitor
Name:
BDBM445179
Synonyms:
1-(cyano-L-prolyl)-4- (4-cyanophenyl)-N- methylindoline-6- carboxamide | US10669234, Example 100 | US11319287, Example 100
Type:
Small organic molecule
Emp. Form.:
C23H21N5O2
Mol. Mass.:
399.4451
SMILES:
CNC(=O)c1cc2N(CCc2c(c1)-c1ccc(cc1)C#N)C(=O)[C@@H]1CCCN1C#N
Structure:
Search PDB for entries with ligand similarity: