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Target
Isocitrate dehydrogenase [NADP] cytoplasmic
Ligand
BDBM445395
Substrate
n/a
Meas. Tech.
Kinase Assay
IC50
550±n/a nM
Citation
 Jiang, L; Geng, M; Zheng, Q; Huang, M; Wan, H; Tang, S; Fu, X; Lan, X; Cao, J; Liu, F; Ding, J Compound having mutant IDH inhibitory activity, preparation method and use thereof US Patent  US10682352 Publication Date 6/16/2020 
Target
Name:
Isocitrate dehydrogenase [NADP] cytoplasmic
Synonyms:
Cytosolic NADP-isocitrate dehydrogenase | IDH | IDH1 | IDHC_HUMAN | IDP | Isocitrate Dehydrogenase (IDH1) | Isocitrate dehydrogenase 1 (IDH1) | NADP(+)-specific ICDH | Oxalosuccinate decarboxylase | PICD
Type:
Protein
Mol. Mass.:
46661.29
Organism:
Homo sapiens (Human)
Description:
O75874
Residue:
414
Sequence:
MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGRHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL
  
Inhibitor
Name:
BDBM445395
Synonyms:
Compound (S)-4,4,-dideutero-5-isopropyl-1-(2-(((S)-1-(4-methyl-2′-(trifluoromethyl)-[3, 4′-bipyridyl]-6-yl)ethyl)amino)pyrimidin-4-yl)imidazolidine-2-one | US10682352, Compound 108
Type:
Small organic molecule
Emp. Form.:
C24H26F3N7O
Mol. Mass.:
485.5047
SMILES:
CC(C)[C@H]1CNC(=O)N1c1ccnc(N[C@@H](C)c2cc(C)c(cn2)-c2ccnc(c2)C(F)(F)F)n1 |r|
Structure:
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