Target
Dipeptidyl peptidase 1
Ligand
BDBM385047
Substrate
n/a
Meas. Tech.
Fluorescence Assay for Recombinant Human (RH) DPP1
IC50
69.2±n/a nM
Citation
 Lonn, HRConnolly, SSwallow, SKarlsson, SPAurell, CPontén, JFDoyle, KJVan De Poël, AJJones, GPWatson, DWMacritchie, JAPalmer, NJ Certain (2S)-N-[(1S)-1-cyano-2-phenylethyl]-1,4-oxazepane-2-carboxamides dipeptidyl peptidase 1 inhibitors US Patent  US10669245 Publication Date 6/2/2020 
Target
Name:
Dipeptidyl peptidase 1
Synonyms:
CATC_HUMAN | CPPI | CTSC | Cathepsin C | Cathepsin J | Dipeptidyl peptidase 1 (DDPI) | Dipeptidyl peptidase 1 (DPPI) | Dipeptidyl peptidase I | Dipeptidyl peptidase I (DPPI)
Type:
Enzyme
Mol. Mass.:
51857.28
Organism:
Homo sapiens (Human)
Description:
P53634
Residue:
463
Sequence:
MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL
  
Inhibitor
Name:
BDBM385047
Synonyms:
(2S)-N-[(1S)-1-Cyano-2-(3',4'-difluorobiphenyl-4-yl)ethyl]-1,4-oxazepane-2- carboxamide | US10287258, Example 7 | US10669245, Example 7 | US11117874, Example 7 | US11655221, Example 7 | US11667615, Example 7 | US11680049, Example 7 | US20230278969, Example 7
Type:
Small organic molecule
Emp. Form.:
C21H21F2N3O2
Mol. Mass.:
385.4071
SMILES:
Fc1ccc(cc1F)-c1ccc(C[C@H](NC(=O)[C@@H]2CNCCCO2)C#N)cc1
Structure:
Search PDB for entries with ligand similarity: