Reaction Details Report a problem with these data
Target
Dipeptidyl peptidase 1
Ligand
BDBM385066
Substrate
n/a
Meas. Tech.
Fluorescence Assay for Recombinant Human (RH) DPP1
IC50
13.5±n/a nM
Citation
 Lonn, HR; Connolly, S; Swallow, S; Karlsson, SP; Aurell, C; Pontén, JF; Doyle, KJ; Van De Poël, AJ; Jones, GP; Watson, DW; Macritchie, JA; Palmer, NJ Certain (2S)-N-[(1S)-1-cyano-2-phenylethyl]-1,4-oxazepane-2-carboxamides dipeptidyl peptidase 1 inhibitors US Patent  US10669245 Publication Date 6/2/2020 
Target
Name:
Dipeptidyl peptidase 1
Synonyms:
CATC_HUMAN | CPPI | CTSC | Cathepsin C | Cathepsin J | Dipeptidyl peptidase 1 (DDPI) | Dipeptidyl peptidase 1 (DPPI) | Dipeptidyl peptidase I | Dipeptidyl peptidase I (DPPI)
Type:
Enzyme
Mol. Mass.:
51857.28
Organism:
Homo sapiens (Human)
Description:
P53634
Residue:
463
Sequence:
MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL
  
Inhibitor
Name:
BDBM385066
Synonyms:
(2S)-N-{(1S)-2-[4-(7-Chloro-3-methyl-2-oxo-2,3-dihydro-1,3-benzoxazol-5-yl)phenyl]- 1-cyanoethyl}-1,4-oxazepane-2-carboxamide | US10287258, Example 26 | US10669245, Example 26 | US11117874, Example 26 | US11655221, Example 26 | US11667615, Example 26 | US11680049, Example 26 | US20230278969, Example 26
Type:
Small organic molecule
Emp. Form.:
C23H23ClN4O4
Mol. Mass.:
454.906
SMILES:
Cn1c2cc(cc(Cl)c2oc1=O)-c1ccc(C[C@H](NC(=O)[C@@H]2CNCCCO2)C#N)cc1
Structure:
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