Reaction Details Report a problem with these data
Target
Ataxin-1
Ligand
BDBM446143
Substrate
n/a
Meas. Tech.
Human ATX Enzyme Inhibition Assay
IC50
4.00±n/a nM
Citation
Hert, J; Hunziker, D; Mattei, P; Mauser, H; Tang, G; Wang, L Bicyclic derivatives US Patent US10669268 Publication Date 6/2/2020
More Info.:
Target
Name:
Ataxin-1
Synonyms:
ATX1 | ATX1_HUMAN | ATXN1 | SCA1
Type:
Protein
Mol. Mass.:
86941.25
Organism:
Homo sapiens (Human)
Description:
P54253
Residue:
815
Sequence:
MKSNQERSNECLPPKKREIPATSRSSEEKAPTLPSDNHRVEGTAWLPGNPGGRGHGGGRHGPAGTSVELGLQQGIGLHKALSTGLDYSPPSAPRSVPVATTLPAAYATPQPGTPVSPVQYAHLPHTFQFIGSSQYSGTYASFIPSQLIPPTANPVTSAVASAAGATTPSQRSQLEAYSTLLANMGSLSQTPGHKAEQQQQQQQQQQQQHQHQQQQQQQQQQQQQQHLSRAPGLITPGSPPPAQQNQYVHISSSPQNTGRTASPPAIPVHLHPHQTMIPHTLTLGPPSQVVMQYADSGSHFVPREATKKAESSRLQQAIQAKEVLNGEMEKSRRYGAPSSADLGLGKAGGKSVPHPYESRHVVVHPSPSDYSSRDPSGVRASVMVLPNSNTPAADLEVQQATHREASPSTLNDKSGLHLGKPGHRSYALSPHTVIQTTHSASEPLPVGLPATAFYAGTQPPVIGYLSGQQQAITYAGSLPQHLVIPGTQPLLIPVGSTDMEASGAAPAIVTSSPQFAAVPHTFVTTALPKSENFNPEALVTQAAYPAMVQAQIHLPVVQSVASPAAAPPTLPPYFMKGSIIQLANGELKKVEDLKTEDFIQSAEISNDLKIDSSTVERIEDSHSPGVAVIQFAVGEHRAQVSVEVLVEYPFFVFGQGWSSCCPERTSQLFDLPCSKLSVGDVCISLTLKNLKNGSVKKGQPVDPASVLLKHSKADGLAGSRHRYAEQENGINQGSAQMLSENGELKFPEKMGLPAAPFLTKIEPSKPAATRKRRWSAPESRKLEKSEDEPPLTLPKPSLIPQEVKICIEGRSNVGK
Inhibitor
Name:
BDBM446143
Synonyms:
US10669268, Example 4.10 | trans-3,5-dichlorobenzyl 5-(1H-benzo[d][1,2,3]triazole-5-carbonyl)hexahydro-1H-pyrrolo[3,4-c]pyridine-2(3H)-carboxylate
Type:
Small organic molecule
Emp. Form.:
C22H21Cl2N5O3
Mol. Mass.:
474.34
SMILES:
Clc1cc(Cl)cc(COC(=O)N2C[C@H]3CCN(C[C@@H]3C2)C(=O)c2ccc3[nH]nnc3c2)c1 |r|