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Target
Ataxin-1
Ligand
BDBM446232
Substrate
n/a
Meas. Tech.
Human ATX Enzyme Inhibition Assay
IC50
2.00±n/a nM
Citation
 Hert, J; Hunziker, D; Mattei, P; Mauser, H; Tang, G; Wang, L Bicyclic derivatives US Patent  US10669268 Publication Date 6/2/2020 
Target
Name:
Ataxin-1
Synonyms:
ATX1 | ATX1_HUMAN | ATXN1 | SCA1
Type:
Protein
Mol. Mass.:
86941.25
Organism:
Homo sapiens (Human)
Description:
P54253
Residue:
815
Sequence:
MKSNQERSNECLPPKKREIPATSRSSEEKAPTLPSDNHRVEGTAWLPGNPGGRGHGGGRHGPAGTSVELGLQQGIGLHKALSTGLDYSPPSAPRSVPVATTLPAAYATPQPGTPVSPVQYAHLPHTFQFIGSSQYSGTYASFIPSQLIPPTANPVTSAVASAAGATTPSQRSQLEAYSTLLANMGSLSQTPGHKAEQQQQQQQQQQQQHQHQQQQQQQQQQQQQQHLSRAPGLITPGSPPPAQQNQYVHISSSPQNTGRTASPPAIPVHLHPHQTMIPHTLTLGPPSQVVMQYADSGSHFVPREATKKAESSRLQQAIQAKEVLNGEMEKSRRYGAPSSADLGLGKAGGKSVPHPYESRHVVVHPSPSDYSSRDPSGVRASVMVLPNSNTPAADLEVQQATHREASPSTLNDKSGLHLGKPGHRSYALSPHTVIQTTHSASEPLPVGLPATAFYAGTQPPVIGYLSGQQQAITYAGSLPQHLVIPGTQPLLIPVGSTDMEASGAAPAIVTSSPQFAAVPHTFVTTALPKSENFNPEALVTQAAYPAMVQAQIHLPVVQSVASPAAAPPTLPPYFMKGSIIQLANGELKKVEDLKTEDFIQSAEISNDLKIDSSTVERIEDSHSPGVAVIQFAVGEHRAQVSVEVLVEYPFFVFGQGWSSCCPERTSQLFDLPCSKLSVGDVCISLTLKNLKNGSVKKGQPVDPASVLLKHSKADGLAGSRHRYAEQENGINQGSAQMLSENGELKFPEKMGLPAAPFLTKIEPSKPAATRKRRWSAPESRKLEKSEDEPPLTLPKPSLIPQEVKICIEGRSNVGK
  
Inhibitor
Name:
BDBM446232
Synonyms:
US10669268, Example 15.27
Type:
Small organic molecule
Emp. Form.:
C24H23Cl2N5O2
Mol. Mass.:
484.378
SMILES:
Clc1cc(Cl)cc(\C=C\C(=O)N2CC[C@@H]3CN(C[C@@H]3CC2)C(=O)c2ccc3[nH]nnc3c2)c1 |r|
Structure:
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