Reaction Details Report a problem with these data
Target
Indoleamine 2,3-dioxygenase 1
Ligand
BDBM446502
Substrate
n/a
Meas. Tech.
Indoleamine-2,3-Dioxygenase 1 Inhibitory Activity
IC50
550±n/a nM
Citation
 Meng, X; Chen, Y; Li, Z; Lu, D; Zhang, M Use of aza-tryptanthrin derivatives as inhibitors of IDO1 and/or TDO US Patent  US10669273 Publication Date 6/2/2020 
Target
Name:
Indoleamine 2,3-dioxygenase 1
Synonyms:
I23O1_HUMAN | IDO | IDO-1 | IDO1 | INDO | Indoleamine 2,3-Dioxygenasae (IDO) | Indoleamine 2,3-dioxygenase | Indoleamine-pyrrole 2,3-dioxygenase
Type:
Enzyme
Mol. Mass.:
45330.80
Organism:
Homo sapiens (Human)
Description:
P14902
Residue:
403
Sequence:
MAHAMENSWTISKEYHIDEEVGFALPNPQENLPDFYNDWMFIAKHLPDLIESGQLRERVEKLNMLSIDHLTDHKSQRLARLVLGCITMAYVWGKGHGDVRKVLPRNIAVPYCQLSKKLELPPILVYADCVLANWKKKDPNKPLTYENMDVLFSFRDGDCSKGFFLVSLLVEIAAASAIKVIPTVFKAMQMQERDTLLKALLEIASCLEKALQVFHQIHDHVNPKAFFSVLRIYLSGWKGNPQLSDGLVYEGFWEDPKEFAGGSAGQSSVFQCFDVLLGIQQTAGGGHAAQFLQDMRRYMPPAHRNFLCSLESNPSVREFVLSKGDAGLREAYDACVKALVSLRSYHLQIVTKYILIPASQQPKENKTSEDPSKLEAKGTGGTDLMNFLKTVRSTTEKSLLKEG
  
Inhibitor
Name:
BDBM446502
Synonyms:
11-((2-(dimethylamino)ethoxy)imino)pyrido[2′,3′:4,5]pyrimido[1,2-α]indole-5(11H)-one | US10669273, Compound CY-1-16
Type:
Small organic molecule
Emp. Form.:
C18H17N5O2
Mol. Mass.:
335.3599
SMILES:
CN(C)CCON=C1c2ccccc2-n2c1nc1ncccc1c2=O |w:6.5|
Structure:
Search PDB for entries with ligand similarity: