Reaction Details Report a problem with these data
Target
Amyloid-beta precursor protein [672-713]
Ligand
BDBM446531
Substrate
n/a
Meas. Tech.
gamma-Secretase Assay
EC50
72.0±n/a nM
Citation
 Bartels, B; Jakob-Roetne, R; Limberg, A; Neidhart, W; Ratni, H; Steiner, S; Reutlinger, M Fused pyrimidine derivatives US Patent  US10669276 Publication Date 6/2/2020 
Target
Name:
Amyloid-beta precursor protein [672-713]
Synonyms:
A4 | A4_HUMAN | AD1 | APP | Amyloid-beta precursor protein aa 672-713 | Amyloid-beta protein 42
Type:
Enzyme Catalytic Domain
Mol. Mass.:
4512.53
Organism:
Homo sapiens (Human)
Description:
P05067[672-713]
Residue:
42
Sequence:
DAEFRHDSGYEVHHQKLVFFAEDVGSNKGAIIGLMVGGVVIA
  
Inhibitor
Name:
BDBM446531
Synonyms:
N2-(3-Methoxy-4-(3-methyl-1H-1,2,4-triazol-1-yl)phenyl)-N4,5,5-trimethyl-7-(3-(trifluoromethyl)bicyclo[1.1.1]pentan-1-yl)-6,7-dihydro-5H-pyrrolo[2,3-d]pyrimidine-2,4-diamine | US10669276, Example 21
Type:
Small organic molecule
Emp. Form.:
C25H29F3N8O
Mol. Mass.:
514.546
SMILES:
CNc1nc(Nc2ccc(c(OC)c2)-n2cnc(C)n2)nc2N(CC(C)(C)c12)C12CC(C1)(C2)C(F)(F)F
Structure:
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