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Target
Proteasome subunit beta type-8
Ligand
BDBM446697
Substrate
n/a
Meas. Tech.
Determination of LMP7 Activity
IC50
<50±n/a nM
Citation
 Klein, M; Schadt, O; Haselmayer, P; Krier, M Boronic acid derivatives US Patent  US10669289 Publication Date 6/2/2020 
Target
Name:
Proteasome subunit beta type-8
Synonyms:
26S proteosome | LMP7 | Low molecular mass protein 7 | Macropain subunit C13 | Multicatalytic endopeptidase complex subunit C13 | PSB8_HUMAN | PSMB5i | PSMB8 | Proteasome component C13 | Proteasome subunit beta type-8 | Proteasome subunit beta-5i | RING10 | Y2
Type:
PROTEIN
Mol. Mass.:
30357.49
Organism:
Homo sapiens (Human)
Description:
ChEMBL_1446797
Residue:
276
Sequence:
MALLDVCGAPRGQRPESALPVAGSGRRSDPGHYSFSMRSPELALPRGMQPTEFFQSLGGDGERNVQIEMAHGTTTLAFKFQHGVIAAVDSRASAGSYISALRVNKVIEINPYLLGTMSGCAADCQYWERLLAKECRLYYLRNGERISVSAASKLLSNMMCQYRGMGLSMGSMICGWDKKGPGLYYVDEHGTRLSGNMFSTGSGNTYAYGVMDSGYRPNLSPEEAYDLGRRAIAYATHRDSYSGGVVNMYHMKEDGWVKVESTDVSDLLHQYREANQ
  
Inhibitor
Name:
BDBM446697
Synonyms:
US10669289, Compound 104
Type:
Small organic molecule
Emp. Form.:
C17H18BBrN2O4S
Mol. Mass.:
437.116
SMILES:
OB(O)[C@H](Cc1cccs1)NC(=O)CN(C(=O)C=C)c1ccc(Br)cc1 |r|
Structure:
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