Reaction Details Report a problem with these data
Target
Ubiquitin carboxyl-terminal hydrolase 30
Ligand
BDBM404530
Substrate
n/a
Meas. Tech.
Biochemical Fluorescence Intensity Kinetic Assay/Biochemical Fluorescence Intensity Assay
IC50
<100±n/a nM
Citation
 Jones, A; Kemp, M; Stockley, M; Gibson, K; Whitlock, G 1-cyano-pyrrolidine compounds as USP30 inhibitors US Patent  US10689345 Publication Date 6/23/2020 
Target
Name:
Ubiquitin carboxyl-terminal hydrolase 30
Synonyms:
Deubiquitinating enzyme 30 | UBP30_HUMAN | USP30 | Ub-specific protease 30 | Ubiquitin carboxyl-terminal hydrolase 30 (USP30) | Ubiquitin thioesterase 30 | Ubiquitin-specific-processing protease 30
Type:
Protein
Mol. Mass.:
58522.90
Organism:
Homo sapiens (Human)
Description:
Q70CQ3
Residue:
517
Sequence:
MLSSRAEAAMTAADRAIQRFLRTGAAVRYKVMKNWGVIGGIAAALAAGIYVIWGPITERKKRRKGLVPGLVNLGNTCFMNSLLQGLSACPAFIRWLEEFTSQYSRDQKEPPSHQYLSLTLLHLLKALSCQEVTDDEVLDASCLLDVLRMYRWQISSFEEQDAHELFHVITSSLEDERDRQPRVTHLFDVHSLEQQSEITPKQITCRTRGSPHPTSNHWKSQHPFHGRLTSNMVCKHCEHQSPVRFDTFDSLSLSIPAATWGHPLTLDHCLHHFISSESVRDVVCDNCTKIEAKGTLNGEKVEHQRTTFVKQLKLGKLPQCLCIHLQRLSWSSHGTPLKRHEHVQFNEFLMMDIYKYHLLGHKPSQHNPKLNKNPGPTLELQDGPGAPTPVLNQPGAPKTQIFMNGACSPSLLPTLSAPMPFPLPVVPDYSSSTYLFRLMAVVVHHGDMHSGHFVTYRRSPPSARNPLSTSNQWLWVSDDTVRKASLQEVLSSSAYLLFYERVLSRMQHQSQECKSEE
  
Inhibitor
Name:
BDBM404530
Synonyms:
(R)-N-(1- cyanopyrrolidin- 3-yl)-2-fluoro-4- (5-fluoro-2- methylpyrimidin- 4-yl)benzamide | US10343992, Example 182 | US10689345, Example 182 | US11066365, Example 182 | US11390584, Example 182
Type:
Small organic molecule
Emp. Form.:
C17H15F2N5O
Mol. Mass.:
343.3307
SMILES:
Cc1ncc(F)c(n1)-c1ccc(C(=O)N[C@@H]2CCN(C2)C#N)c(F)c1
Structure:
Search PDB for entries with ligand similarity: