Target
Ubiquitin carboxyl-terminal hydrolase 30
Ligand
BDBM447731
Substrate
n/a
Meas. Tech.
Biochemical Fluorescence Intensity Kinetic Assay/Biochemical Fluorescence Intensity Assay
IC50
<100±n/a nM
Citation
 Jones, AKemp, MStockley, MGibson, KWhitlock, G 1-cyano-pyrrolidine compounds as USP30 inhibitors US Patent  US10689345 Publication Date 6/23/2020 
Target
Name:
Ubiquitin carboxyl-terminal hydrolase 30
Synonyms:
Deubiquitinating enzyme 30 | UBP30_HUMAN | USP30 | Ub-specific protease 30 | Ubiquitin carboxyl-terminal hydrolase 30 (USP30) | Ubiquitin thioesterase 30 | Ubiquitin-specific-processing protease 30
Type:
Protein
Mol. Mass.:
58522.90
Organism:
Homo sapiens (Human)
Description:
Q70CQ3
Residue:
517
Sequence:
MLSSRAEAAMTAADRAIQRFLRTGAAVRYKVMKNWGVIGGIAAALAAGIYVIWGPITERKKRRKGLVPGLVNLGNTCFMNSLLQGLSACPAFIRWLEEFTSQYSRDQKEPPSHQYLSLTLLHLLKALSCQEVTDDEVLDASCLLDVLRMYRWQISSFEEQDAHELFHVITSSLEDERDRQPRVTHLFDVHSLEQQSEITPKQITCRTRGSPHPTSNHWKSQHPFHGRLTSNMVCKHCEHQSPVRFDTFDSLSLSIPAATWGHPLTLDHCLHHFISSESVRDVVCDNCTKIEAKGTLNGEKVEHQRTTFVKQLKLGKLPQCLCIHLQRLSWSSHGTPLKRHEHVQFNEFLMMDIYKYHLLGHKPSQHNPKLNKNPGPTLELQDGPGAPTPVLNQPGAPKTQIFMNGACSPSLLPTLSAPMPFPLPVVPDYSSSTYLFRLMAVVVHHGDMHSGHFVTYRRSPPSARNPLSTSNQWLWVSDDTVRKASLQEVLSSSAYLLFYERVLSRMQHQSQECKSEE
  
Inhibitor
Name:
BDBM447731
Synonyms:
(R)-N-(1- cyanopyrrolidin- 3-yl)-3-(3,4- dimethylphenyl) isoxazole-5- | US10689345, Example 271
Type:
Small organic molecule
Emp. Form.:
C17H18N4O2
Mol. Mass.:
310.3504
SMILES:
Cc1ccc(cc1C)-c1cc(on1)C(=O)N[C@H]1CCN(C1)C#N
Structure:
Search PDB for entries with ligand similarity: