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Target
N-acylethanolamine-hydrolyzing acid amidase
Ligand
BDBM447462
Substrate
n/a
Meas. Tech.
Inhibition of Test Compounds NAAA Assay
IC50
>1000±n/a nM
Citation
 Malamas, MS; Makriyannis, A; Farah, SI; Zvonok, AM; Alapafuja, SO N-acylethanolamine hydrolyzing acid amidase (NAAA) inhibitors and use thereof US Patent  US10689357 Publication Date 6/23/2020 
Target
Name:
N-acylethanolamine-hydrolyzing acid amidase
Synonyms:
ASAH-like protein | ASAHL | Acid ceramidase-like protein | N-acylethanolamine-hydrolyzing acid amidase | N-acylsphingosine amidohydrolase-like | N-acylsphingosine-amidohydrolase | NAAA | NAAA_HUMAN | PLT
Type:
Enzyme
Mol. Mass.:
40073.12
Organism:
Homo sapiens (Human)
Description:
Q02083
Residue:
359
Sequence:
MRTADREARPGLPSLLLLLLAGAGLSAASPPAAPRFNVSLDSVPELRWLPVLRHYDLDLVRAAMAQVIGDRVPKWVHVLIGKVVLELERFLPQPFTGEIRGMCDFMNLSLADCLLVNLAYESSVFCTSIVAQDSRGHIYHGRNLDYPFGNVLRKLTVDVQFLKNGQIAFTGTTFIGYVGLWTGQSPHKFTVSGDERDKGWWWENAIAALFRRHIPVSWLIRATLSESENFEAAVGKLAKTPLIADVYYIVGGTSPREGVVITRNRDGPADIWPLDPLNGAWFRVETNYDHWKPAPKEDDRRTSAIKALNATGQANLSLEALFQILSVVPVYNNFTIYTTVMSAGSPDKYMTRIRNPSRK
  
Inhibitor
Name:
BDBM447462
Synonyms:
US10689357, Example 1
Type:
Small organic molecule
Emp. Form.:
C15H16N2O2S
Mol. Mass.:
288.365
SMILES:
COc1ccc(\C=C\C(=O)N[C@H]2C[C@H](C2)N=C=S)cc1 |r,wU:11.10,13.15,(-8.95,-2.47,;-7.61,-3.24,;-6.28,-2.47,;-6.28,-.93,;-4.94,-.16,;-3.61,-.93,;-2.28,-.16,;-.94,-.93,;.39,-.16,;.39,1.38,;1.72,-.93,;3.06,-.16,;3.46,1.33,;4.94,.93,;4.55,-.56,;6.28,1.7,;7.61,2.47,;8.95,3.24,;-3.61,-2.47,;-4.94,-3.24,)|
Structure:
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