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Target
N-acylethanolamine-hydrolyzing acid amidase
Ligand
BDBM447475
Substrate
n/a
Meas. Tech.
Inhibition of Test Compounds NAAA Assay
IC50
550±n/a nM
Citation
 Malamas, MS; Makriyannis, A; Farah, SI; Zvonok, AM; Alapafuja, SO N-acylethanolamine hydrolyzing acid amidase (NAAA) inhibitors and use thereof US Patent  US10689357 Publication Date 6/23/2020 
Target
Name:
N-acylethanolamine-hydrolyzing acid amidase
Synonyms:
ASAH-like protein | ASAHL | Acid ceramidase-like protein | N-acylethanolamine-hydrolyzing acid amidase | N-acylsphingosine amidohydrolase-like | N-acylsphingosine-amidohydrolase | NAAA | NAAA_HUMAN | PLT
Type:
Enzyme
Mol. Mass.:
40073.12
Organism:
Homo sapiens (Human)
Description:
Q02083
Residue:
359
Sequence:
MRTADREARPGLPSLLLLLLAGAGLSAASPPAAPRFNVSLDSVPELRWLPVLRHYDLDLVRAAMAQVIGDRVPKWVHVLIGKVVLELERFLPQPFTGEIRGMCDFMNLSLADCLLVNLAYESSVFCTSIVAQDSRGHIYHGRNLDYPFGNVLRKLTVDVQFLKNGQIAFTGTTFIGYVGLWTGQSPHKFTVSGDERDKGWWWENAIAALFRRHIPVSWLIRATLSESENFEAAVGKLAKTPLIADVYYIVGGTSPREGVVITRNRDGPADIWPLDPLNGAWFRVETNYDHWKPAPKEDDRRTSAIKALNATGQANLSLEALFQILSVVPVYNNFTIYTTVMSAGSPDKYMTRIRNPSRK
  
Inhibitor
Name:
BDBM447475
Synonyms:
US10689357, Example 13
Type:
Small organic molecule
Emp. Form.:
C15H14N2O2S
Mol. Mass.:
286.349
SMILES:
COc1ccc(cc1)C#CC(=O)N[C@H]1C[C@H](C1)N=C=S |r,wU:13.13,15.18,(-8.95,-3.24,;-7.61,-4.01,;-6.28,-3.24,;-6.28,-1.7,;-4.94,-.93,;-3.61,-1.7,;-3.61,-3.24,;-4.94,-4.01,;-2.28,-.93,;-.94,-.16,;.39,.61,;.39,2.15,;1.72,-.16,;3.06,.61,;3.46,2.1,;4.94,1.7,;4.55,.21,;6.28,2.47,;7.61,3.24,;8.95,4.01,)|
Structure:
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