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Target
N-acylethanolamine-hydrolyzing acid amidase
Ligand
BDBM447491
Substrate
n/a
Meas. Tech.
Inhibition of Test Compounds NAAA Assay
IC50
55±n/a nM
Citation
 Malamas, MS; Makriyannis, A; Farah, SI; Zvonok, AM; Alapafuja, SO N-acylethanolamine hydrolyzing acid amidase (NAAA) inhibitors and use thereof US Patent  US10689357 Publication Date 6/23/2020 
Target
Name:
N-acylethanolamine-hydrolyzing acid amidase
Synonyms:
ASAH-like protein | ASAHL | Acid ceramidase-like protein | N-acylethanolamine-hydrolyzing acid amidase | N-acylsphingosine amidohydrolase-like | N-acylsphingosine-amidohydrolase | NAAA | NAAA_HUMAN | PLT
Type:
Enzyme
Mol. Mass.:
40073.12
Organism:
Homo sapiens (Human)
Description:
Q02083
Residue:
359
Sequence:
MRTADREARPGLPSLLLLLLAGAGLSAASPPAAPRFNVSLDSVPELRWLPVLRHYDLDLVRAAMAQVIGDRVPKWVHVLIGKVVLELERFLPQPFTGEIRGMCDFMNLSLADCLLVNLAYESSVFCTSIVAQDSRGHIYHGRNLDYPFGNVLRKLTVDVQFLKNGQIAFTGTTFIGYVGLWTGQSPHKFTVSGDERDKGWWWENAIAALFRRHIPVSWLIRATLSESENFEAAVGKLAKTPLIADVYYIVGGTSPREGVVITRNRDGPADIWPLDPLNGAWFRVETNYDHWKPAPKEDDRRTSAIKALNATGQANLSLEALFQILSVVPVYNNFTIYTTVMSAGSPDKYMTRIRNPSRK
  
Inhibitor
Name:
BDBM447491
Synonyms:
US10689357, Example 28
Type:
Small organic molecule
Emp. Form.:
C19H15F2NO3S
Mol. Mass.:
375.389
SMILES:
COc1ccc(cc1F)-c1ccc(C(=O)O[C@H]2C[C@H](C2)N=C=S)c(F)c1 |r,wU:16.16,18.21,(-11.73,2.18,;-11.21,.74,;-9.67,.74,;-8.9,2.07,;-7.36,2.07,;-6.59,.74,;-7.36,-.6,;-8.9,-.6,;-9.67,-1.93,;-5.05,.74,;-4.28,-.6,;-2.74,-.6,;-1.97,.74,;-.43,.74,;.34,2.07,;.34,-.6,;1.88,-.6,;2.97,.49,;4.37,-.6,;2.97,-1.68,;6.13,-.6,;7.17,.83,;8.2,2.25,;-2.74,2.07,;-1.97,3.41,;-4.28,2.07,)|
Structure:
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