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Target
N-acylethanolamine-hydrolyzing acid amidase
Ligand
BDBM447496
Substrate
n/a
Meas. Tech.
Inhibition of Test Compounds NAAA Assay
IC50
55±n/a nM
Citation
 Malamas, MS; Makriyannis, A; Farah, SI; Zvonok, AM; Alapafuja, SO N-acylethanolamine hydrolyzing acid amidase (NAAA) inhibitors and use thereof US Patent  US10689357 Publication Date 6/23/2020 
Target
Name:
N-acylethanolamine-hydrolyzing acid amidase
Synonyms:
ASAH-like protein | ASAHL | Acid ceramidase-like protein | N-acylethanolamine-hydrolyzing acid amidase | N-acylsphingosine amidohydrolase-like | N-acylsphingosine-amidohydrolase | NAAA | NAAA_HUMAN | PLT
Type:
Enzyme
Mol. Mass.:
40073.12
Organism:
Homo sapiens (Human)
Description:
Q02083
Residue:
359
Sequence:
MRTADREARPGLPSLLLLLLAGAGLSAASPPAAPRFNVSLDSVPELRWLPVLRHYDLDLVRAAMAQVIGDRVPKWVHVLIGKVVLELERFLPQPFTGEIRGMCDFMNLSLADCLLVNLAYESSVFCTSIVAQDSRGHIYHGRNLDYPFGNVLRKLTVDVQFLKNGQIAFTGTTFIGYVGLWTGQSPHKFTVSGDERDKGWWWENAIAALFRRHIPVSWLIRATLSESENFEAAVGKLAKTPLIADVYYIVGGTSPREGVVITRNRDGPADIWPLDPLNGAWFRVETNYDHWKPAPKEDDRRTSAIKALNATGQANLSLEALFQILSVVPVYNNFTIYTTVMSAGSPDKYMTRIRNPSRK
  
Inhibitor
Name:
BDBM447496
Synonyms:
US10689357, Example 32
Type:
Small organic molecule
Emp. Form.:
C17H22N2OS
Mol. Mass.:
302.434
SMILES:
O=C(CCCCCc1ccccc1)N[C@H]1C[C@H](C1)N=C=S |r,wU:14.14,16.19,(.6,1.07,;.6,-.47,;-.73,-1.24,;-2.07,-.47,;-3.4,-1.24,;-4.74,-.47,;-6.07,-1.24,;-7.4,-.47,;-8.74,-1.24,;-10.07,-.47,;-10.07,1.07,;-8.74,1.84,;-7.4,1.07,;1.93,-1.24,;3.27,-.47,;3.67,1.01,;5.29,.7,;4.75,-.87,;6.72,1.52,;6.72,3.16,;6.72,4.8,)|
Structure:
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