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Target
N-acylethanolamine-hydrolyzing acid amidase
Ligand
BDBM447500
Substrate
n/a
Meas. Tech.
Inhibition of Test Compounds NAAA Assay
IC50
550±n/a nM
Citation
 Malamas, MS; Makriyannis, A; Farah, SI; Zvonok, AM; Alapafuja, SO N-acylethanolamine hydrolyzing acid amidase (NAAA) inhibitors and use thereof US Patent  US10689357 Publication Date 6/23/2020 
Target
Name:
N-acylethanolamine-hydrolyzing acid amidase
Synonyms:
ASAH-like protein | ASAHL | Acid ceramidase-like protein | N-acylethanolamine-hydrolyzing acid amidase | N-acylsphingosine amidohydrolase-like | N-acylsphingosine-amidohydrolase | NAAA | NAAA_HUMAN | PLT
Type:
Enzyme
Mol. Mass.:
40073.12
Organism:
Homo sapiens (Human)
Description:
Q02083
Residue:
359
Sequence:
MRTADREARPGLPSLLLLLLAGAGLSAASPPAAPRFNVSLDSVPELRWLPVLRHYDLDLVRAAMAQVIGDRVPKWVHVLIGKVVLELERFLPQPFTGEIRGMCDFMNLSLADCLLVNLAYESSVFCTSIVAQDSRGHIYHGRNLDYPFGNVLRKLTVDVQFLKNGQIAFTGTTFIGYVGLWTGQSPHKFTVSGDERDKGWWWENAIAALFRRHIPVSWLIRATLSESENFEAAVGKLAKTPLIADVYYIVGGTSPREGVVITRNRDGPADIWPLDPLNGAWFRVETNYDHWKPAPKEDDRRTSAIKALNATGQANLSLEALFQILSVVPVYNNFTIYTTVMSAGSPDKYMTRIRNPSRK
  
Inhibitor
Name:
BDBM447500
Synonyms:
US10689357, Example 36
Type:
Small organic molecule
Emp. Form.:
C16H19N3O2S
Mol. Mass.:
317.406
SMILES:
COc1ccc(cc1)N1CC(C1)C(=O)N[C@H]1C[C@H](C1)N=C=S |r,wU:15.16,17.21,(-7.89,-4.17,;-6.55,-4.94,;-5.22,-4.17,;-5.22,-2.63,;-3.89,-1.86,;-2.55,-2.63,;-2.55,-4.17,;-3.89,-4.94,;-1.22,-1.86,;-.82,-.37,;.67,-.77,;.27,-2.26,;2,,;2,1.54,;3.33,-.77,;4.67,,;5.07,1.49,;6.63,1.08,;6.16,-.4,;7.98,1.83,;8.01,3.37,;8.04,4.91,)|
Structure:
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