Target
Nuclear receptor ROR-gamma
Ligand
BDBM385454
Substrate
n/a
Meas. Tech.
Biological Assay for RORgammaT Activity
IC50
2.00±n/a nM
Citation
 Lapointe, BTFuller, PHGunaydin, HLiu, KScott, METrotter, BWZhang, H Substituted indazole compounds as RORgammaT inhibitors and uses thereof US Patent  US10689369 Publication Date 6/23/2020 
Target
Name:
Nuclear receptor ROR-gamma
Synonyms:
NR1F3 | Nuclear receptor ROR-gamma | Nuclear receptor ROR-gamma (RORC) | Nuclear receptor subfamily 1 group F member 3 | RAR-related orphan receptor C (RORc) | RORC | RORG | RORG_HUMAN | RZRG | Retinoid-related orphan receptor-gamma | Retinoid-related orphan receptor-gamma (RORc)
Type:
Enzyme Catalytic Domain
Mol. Mass.:
58218.40
Organism:
Homo sapiens (Human)
Description:
P51449
Residue:
518
Sequence:
MDRAPQRQHRASRELLAAKKTHTSQIEVIPCKICGDKSSGIHYGVITCEGCKGFFRRSQRCNAAYSCTRQQNCPIDRTSRNRCQHCRLQKCLALGMSRDAVKFGRMSKKQRDSLHAEVQKQLQQRQQQQQEPVVKTPPAGAQGADTLTYTLGLPDGQLPLGSSPDLPEASACPPGLLKASGSGPSYSNNLAKAGLNGASCHLEYSPERGKAEGRESFYSTGSQLTPDRCGLRFEEHRHPGLGELGQGPDSYGSPSFRSTPEAPYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFSTETESPVGLSK
  
Inhibitor
Name:
BDBM385454
Synonyms:
4-((R or S)-1-(2- chloro-6-cyclopropyl- 3-fluorobenzoyl)-6- (3-methoxyazetidine- 1-carbonyl)-4,5,6,7- tetrahydro-1H- indazol-3- yl)cyclohex-3-ene-1- carboxylic acid | US10287272, Example 4E | US10689369, Example 4E
Type:
Small organic molecule
Emp. Form.:
C29H31ClFN3O5
Mol. Mass.:
556.025
SMILES:
COC1CN(C1)C(=O)C1CCc2c(C1)n(nc2C1=CCC(CC1)C(O)=O)C(=O)c1c(Cl)c(F)ccc1C1CC1 |t:20|
Structure:
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