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Target
Orexin/Hypocretin receptor type 1
Ligand
BDBM185332
Substrate
n/a
Meas. Tech.
FLIPR Assay
IC50
8.00±n/a nM
Citation
 Fieldhouse, C; Glen, A; Maine, S; Fujimoto, T; Robinson, JS 1,2-substituted cyclopentanes as orexin receptor antagonists US Patent  US10689373 Publication Date 6/23/2020 
Target
Name:
Orexin/Hypocretin receptor type 1
Synonyms:
HCRTR1 | Hypocretin receptor type 1 | OX1R_HUMAN | Orexin receptor type 1 | Orexin receptor type 1 (OR 1) | Orexin receptor type 1 (OR-1) | Orexin receptor type 1 (OX1) | Orexin receptor type 1 (OX1R) | Orexin receptor type 1 (OxR1) | Ox1r
Type:
Protein
Mol. Mass.:
47554.50
Organism:
Homo sapiens (Human)
Description:
O43613
Residue:
425
Sequence:
MEPSATPGAQMGVPPGSREPSPVPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFVVALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAIMVPQAAVMECSSVLPELANRTRLFSVCDERWADDLYPKIYHSCFFIVTYLAPLGLMAMAYFQIFRKLWGRQIPGTTSALVRNWKRPSDQLGDLEQGLSGEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPCGSLKAPSPRSSASHKSLSLQSRCSISKISEHVVLTSVTTVLP
  
Inhibitor
Name:
BDBM185332
Synonyms:
US10011588, Example 155 | US10689373, Example 155 | US9156829, 154 | US9156829, 155
Type:
Small organic molecule
Emp. Form.:
C20H20F3N7O
Mol. Mass.:
431.4143
SMILES:
CC1(CCCC1NC(=O)c1ncccc1-n1nccn1)Nc1ccc(cn1)C(F)(F)F
Structure:
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