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Target
Sigma non-opioid intracellular receptor 1
Ligand
BDBM448111
Substrate
n/a
Meas. Tech.
Radioligand Assay
Ki
>500±n/a nM
Citation
 Virgili-Bernado, M; Almansa-Rosales, C; Alegret-Molina, C OXA-Diazaspiro compounds having activity against pain US Patent  US10689398 Publication Date 6/23/2020 
Target
Name:
Sigma non-opioid intracellular receptor 1
Synonyms:
Aging-associated gene 8 protein | OPRS1 | SGMR1_HUMAN | SIG-1R | SIGMAR1 | SR-BP | SR31747-binding protein | SRBP | Sigma 1-type opioid receptor | Sigma opioid receptor | Sigma1R | hSigmaR1
Type:
Enzyme Catalytic Domain
Mol. Mass.:
25124.85
Organism:
Homo sapiens (Human)
Description:
Q99720
Residue:
223
Sequence:
MQWAVGRRWAWAALLLAVAAVLTQVVWLWLGTQSFVFQREEIAQLARQYAGLDHELAFSRLIVELRRLHPGHVLPDEELQWVFVNAGGWMGAMCLLHASLSEYVLLFGTALGSRGHSGRYWAEISDTIISGTFHQWREGTTKSEVFYPGETVVHGPGEATAVEWGPNTWMVEYGRGVIPSTLAFALADTVFSTQDFLTLFYTLRSYARGLRLELTTYLFGQDP
  
Inhibitor
Name:
BDBM448111
Synonyms:
7-benzyl-12-ethyl-4-oxa-7,12-diazadispiro[2.1.5.3]tridecane | US10689398, Example 17
Type:
Small organic molecule
Emp. Form.:
C19H28N2O
Mol. Mass.:
300.4384
SMILES:
CCN1CC2(CC2)OC2(CCCN(Cc3ccccc3)C2)C1
Structure:
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