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Target
Sigma non-opioid intracellular receptor 1
Ligand
BDBM448136
Substrate
n/a
Meas. Tech.
Radioligand Assay
Ki
>500±n/a nM
Citation
 Virgili-Bernado, M; Almansa-Rosales, C; Alegret-Molina, C OXA-Diazaspiro compounds having activity against pain US Patent  US10689398 Publication Date 6/23/2020 
Target
Name:
Sigma non-opioid intracellular receptor 1
Synonyms:
Aging-associated gene 8 protein | OPRS1 | SGMR1_HUMAN | SIG-1R | SIGMAR1 | SR-BP | SR31747-binding protein | SRBP | Sigma 1-type opioid receptor | Sigma opioid receptor | Sigma1R | hSigmaR1
Type:
Enzyme Catalytic Domain
Mol. Mass.:
25124.85
Organism:
Homo sapiens (Human)
Description:
Q99720
Residue:
223
Sequence:
MQWAVGRRWAWAALLLAVAAVLTQVVWLWLGTQSFVFQREEIAQLARQYAGLDHELAFSRLIVELRRLHPGHVLPDEELQWVFVNAGGWMGAMCLLHASLSEYVLLFGTALGSRGHSGRYWAEISDTIISGTFHQWREGTTKSEVFYPGETVVHGPGEATAVEWGPNTWMVEYGRGVIPSTLAFALADTVFSTQDFLTLFYTLRSYARGLRLELTTYLFGQDP
  
Inhibitor
Name:
BDBM448136
Synonyms:
(R)-2-isobutyl-8- isopropyl-6-methyl-5-oxa- 2,8-diazaspiro[3.5]nonan- 7-one | US10689398, Example 42
Type:
Small organic molecule
Emp. Form.:
C14H26N2O2
Mol. Mass.:
254.3684
SMILES:
CC(C)CN1CC2(C1)CN(C(C)C)C(=O)[C@@H](C)O2 |r|
Structure:
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