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Target
Sigma non-opioid intracellular receptor 1
Ligand
BDBM448157
Substrate
n/a
Meas. Tech.
Radioligand Assay
Ki
>500±n/a nM
Citation
 Virgili-Bernado, M; Almansa-Rosales, C; Alegret-Molina, C OXA-Diazaspiro compounds having activity against pain US Patent  US10689398 Publication Date 6/23/2020 
Target
Name:
Sigma non-opioid intracellular receptor 1
Synonyms:
Aging-associated gene 8 protein | OPRS1 | SGMR1_HUMAN | SIG-1R | SIGMAR1 | SR-BP | SR31747-binding protein | SRBP | Sigma 1-type opioid receptor | Sigma opioid receptor | Sigma1R | hSigmaR1
Type:
Enzyme Catalytic Domain
Mol. Mass.:
25124.85
Organism:
Homo sapiens (Human)
Description:
Q99720
Residue:
223
Sequence:
MQWAVGRRWAWAALLLAVAAVLTQVVWLWLGTQSFVFQREEIAQLARQYAGLDHELAFSRLIVELRRLHPGHVLPDEELQWVFVNAGGWMGAMCLLHASLSEYVLLFGTALGSRGHSGRYWAEISDTIISGTFHQWREGTTKSEVFYPGETVVHGPGEATAVEWGPNTWMVEYGRGVIPSTLAFALADTVFSTQDFLTLFYTLRSYARGLRLELTTYLFGQDP
  
Inhibitor
Name:
BDBM448157
Synonyms:
(2S,6R)-9-benzyl-4-ethyl- 2-methyl-1-oxa-4,9- diazaspiro[5.6]dodecan-3- one | US10689398, Example 62
Type:
Small organic molecule
Emp. Form.:
C19H28N2O2
Mol. Mass.:
316.4378
SMILES:
CCN1C[C@]2(CCCN(Cc3ccccc3)CC2)O[C@@H](C)C1=O |r|
Structure:
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