Reaction Details Report a problem with these data
Target
Thymidine kinase, cytosolic
Ligand
BDBM448404
Substrate
n/a
Meas. Tech.
Inhibition Assay
IC50
>10000±n/a nM
Citation
 Eckhardt, M; Gollner, A; Langkopf, E; Wagner, H; Wiedenmayer, D Heteroaromatic carboxamide derivatives as plasma kallikrein inhibitors US Patent  US10695334 Publication Date 6/30/2020 
Target
Name:
Thymidine kinase, cytosolic
Synonyms:
KITH_HUMAN | TK1
Type:
PROTEIN
Mol. Mass.:
25476.50
Organism:
Homo sapiens (Human)
Description:
ChEMBL_1333884
Residue:
234
Sequence:
MSCINLPTVLPGSPSKTRGQIQVILGPMFSGKSTELMRRVRRFQIAQYKCLVIKYAKDTRYSSSFCTHDRNTMEALPACLLRDVAQEALGVAVIGIDEGQFFPDIVEFCEAMANAGKTVIVAALDGTFQRKPFGAILNLVPLAESVVKLTAVCMECFREAAYTKRLGTEKEVEVIGGADKYHSVCRLCYFKKASGQPAGPDNKENCPVPGKPGEAVAARKLFAPQQILQCSPAN
  
Inhibitor
Name:
BDBM448404
Synonyms:
1-{[6-(3-Cyano-3-methylpyrrolidin-1-yl)-2-methylpyridin-3-yl]methyl}-N-[(6R)-3-methyl- | US10695334, Example 71
Type:
Small organic molecule
Emp. Form.:
C24H28N8O
Mol. Mass.:
444.5321
SMILES:
Cc1[nH]nc2[C@@H](CCc12)NC(=O)c1cnn(Cc2ccc(nc2C)N2CCC(C)(C2)C#N)c1 |r|
Structure:
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