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Target
Thymidine kinase, cytosolic
Ligand
BDBM448427
Substrate
n/a
Meas. Tech.
Inhibition Assay
IC50
>10000±n/a nM
Citation
 Eckhardt, M; Gollner, A; Langkopf, E; Wagner, H; Wiedenmayer, D Heteroaromatic carboxamide derivatives as plasma kallikrein inhibitors US Patent  US10695334 Publication Date 6/30/2020 
Target
Name:
Thymidine kinase, cytosolic
Synonyms:
KITH_HUMAN | TK1
Type:
PROTEIN
Mol. Mass.:
25476.50
Organism:
Homo sapiens (Human)
Description:
ChEMBL_1333884
Residue:
234
Sequence:
MSCINLPTVLPGSPSKTRGQIQVILGPMFSGKSTELMRRVRRFQIAQYKCLVIKYAKDTRYSSSFCTHDRNTMEALPACLLRDVAQEALGVAVIGIDEGQFFPDIVEFCEAMANAGKTVIVAALDGTFQRKPFGAILNLVPLAESVVKLTAVCMECFREAAYTKRLGTEKEVEVIGGADKYHSVCRLCYFKKASGQPAGPDNKENCPVPGKPGEAVAARKLFAPQQILQCSPAN
  
Inhibitor
Name:
BDBM448427
Synonyms:
1-[(6-{6,6-Difluoro-3-azabicyclo[3.1.0]hexan-3-yl}- | US10695334, Example 89
Type:
Small organic molecule
Emp. Form.:
C23H25F2N7O
Mol. Mass.:
453.4877
SMILES:
Cc1[nH]nc2[C@@H](CCc12)NC(=O)c1cn(Cc2ccc(nc2C)N2CC3C(C2)C3(F)F)cn1 |r|
Structure:
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