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Target
Tyrosine-protein kinase JAK1 [837-1142]
Ligand
BDBM246868
Substrate
n/a
Meas. Tech.
In vitro JAK Kinase Assay
IC50
<5.00±n/a nM
Citation
 Huang, T; Xue, C Piperidin-4-yl azetidine derivatives as JAK1 inhibitors US Patent  US10695337 Publication Date 6/30/2020 
Target
Name:
Tyrosine-protein kinase JAK1 [837-1142]
Synonyms:
JAK1 | JAK1 (aa 837-1142) | JAK1A | JAK1B | JAK1_HUMAN | Tyrosine-protein kinase JAK1 | Tyrosine-protein kinase JAK1 (837-1142) | Tyrosine-protein kinase JAK1 (aa 837-1142)
Type:
n/a
Mol. Mass.:
35230.04
Organism:
Homo sapiens (Human)
Description:
P23458[837-1142]
Residue:
306
Sequence:
FFRAIMRDINKLEEQNPDIVSEKKPATEVDPTHFEKRFLKRIRDLGEGHFGKVELCRYDPEGDNTGEQVAVKSLKPESGGNHIADLKKEIEILRNLYHENIVKYKGICTEDGGNGIKLIMEFLPSGSLKEYLPKNKNKINLKQQLKYAVQICKGMDYLGSRQYVHRDLAARNVLVESEHQVKIGDFGLTKAIETDKEYYTVKDDRDSPVFWYAPECLMQSKFYIASDVWSFGVTLHELLTYCDSDSSPMALFLKMIGPTHGQMTVTRLVNTLKEGKRLPCPPNCPDEVYQLMRKCWEFQPSNRTSF
  
Inhibitor
Name:
BDBM246868
Synonyms:
US10053465, 7 | US10065963, Compound 7 | US10125150, Example 7 | US10336759, # 7 | US10479803, Example 7 | US10519163, Example 7 | US10675284, Example 7 | US10875847, Compound INCB39110 | US11084822, Example 7 | US11130767, # 7 | US11136326, Example 7 | US11285140, Example 364 | US11304949, Compound 1 | US11324749, Comp. No. 1 | US11406640, Comp. No. 1 | US11596632, Comp. No. 1 | US9732097, Example 7 | US9999619, Example 364 | {1-{1-[3-Fluoro-2- (trifluoromethyl) isonicotinoyl] piperidin-4- yl}-3-[4-(7H- pyrrolo[2,3- d]pyrimidin-4-yl)- 1H-pyrazol-1- yl]azetidin-3- yl}acetonitrile
Type:
Small organic molecule
Emp. Form.:
C26H23F4N9O
Mol. Mass.:
553.5141
SMILES:
Fc1c(ccnc1C(F)(F)F)C(=O)N1CCC(CC1)N1CC(CC#N)(C1)n1cc(cn1)-c1ncnc2[nH]ccc12
Structure:
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