Target
Tyrosine-protein kinase JAK2 [828-1132]
Ligand
BDBM400286
Substrate
n/a
Meas. Tech.
In vitro JAK Kinase Assay
IC50
<10.00±n/a nM
Citation
 Huang, TXue, C Piperidin-4-yl azetidine derivatives as JAK1 inhibitors US Patent  US10695337 Publication Date 6/30/2020
Target
Name:
Tyrosine-protein kinase JAK2 [828-1132]
Synonyms:
Tyrosine-protein kinase JAK2 (aa 828-1132)
Type:
Enzyme Catalytic Domain
Mol. Mass.:
35522.23
Organism:
Homo sapiens (Human)
Description:
aa 828-1132
Residue:
304
Sequence:
ALGFSGAFEDRDPTQFEERHLKFLQQLGKGNFGSVEMCRYDPLQDNTGEVVAVKKLQHSTEEHLRDFEREIEILKSLQHDNIVKYKGVCYSAGRRNLKLIMEYLPYGSLRDYLQKHKERIDHIKLLQYTSQICKGMEYLGTKRYIHRDLATRNILVENENRVKIGDFGLTKVLPQDKEYYKVKEPGESPIFWYAPESLTESKFSVASDVWSFGVVLYELFTYIEKSKSPPAEFMRMIGNDKQGQMIVFHLIELLKNNGRLPRPDGCPDEIYMIMTECWNNNVNQRPSFRDLALRVDQIRDNMAG
  
Inhibitor
Name:
BDBM400286
Synonyms:
US10695337, Example 40 | US11285140, Example 40 | US9999619, Example 41
Type:
Small organic molecule
Emp. Form.:
C27H27FN8O2
Mol. Mass.:
514.5541
SMILES:
COc1cc(F)ccc1C(=O)N1CCC(CC1)N1CC(CC#N)(C1)n1cc(cn1)-c1ncnc2[nH]ccc12
Structure:
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