Reaction Details Report a problem with these data
Target
Free fatty acid receptor 1
Ligand
BDBM298452
Substrate
n/a
EC50
4.00±n/a nM
Citation
 Eckhardt, M; Wagner, H; Peters, S Indanylaminopyridylcyclopropanecarboxylic acids, pharmaceutical compositions and uses thereof US Patent  US10125101 Publication Date 11/13/2018 
Target
Name:
Free fatty acid receptor 1
Synonyms:
FFAR1 | FFAR1_HUMAN | G-protein Coupled Receptor 40 | GPR40
Type:
G Protein-Coupled Receptor (GPCR)
Mol. Mass.:
31473.32
Organism:
Homo sapiens (Human)
Description:
O14842
Residue:
300
Sequence:
MDLPPQLSFGLYVAAFALGFPLNVLAIRGATAHARLRLTPSLVYALNLGCSDLLLTVSLPLKAVEALASGAWPLPASLCPVFAVAHFFPLYAGGGFLAALSAGRYLGAAFPLGYQAFRRPCYSWGVCAAIWALVLCHLGLVFGLEAPGGWLDHSNTSLGINTPVNGSPVCLEAWDPASAGPARFSLSLLLFFLPLAITAFCYVGCLRALARSGLTHRRKLRAAWVAGGALLTLLLCVGPYNASNVASFLYPNLGGSWRKLGLITGAWSVVLNPLVTGYLGRGPGLKTVCAARTQGGKSQK
  
Inhibitor
Name:
BDBM298452
Synonyms:
(1S,2S)-2-(5-{(R)-7-Fluoro-4-[4-(3-hydroxy-3-methyl-butoxy)-2,6-dimethyl-phenyl]-indan-1-ylamino}-pyridin-2-yl)-cyclopropanecarboxylic acid | US10125101, Example 2
Type:
Small organic molecule
Emp. Form.:
C31H35FN2O4
Mol. Mass.:
518.619
SMILES:
Cc1cc(OCCC(C)(C)O)cc(C)c1-c1ccc(F)c2[C@@H](CCc12)Nc1ccc(nc1)[C@H]1C[C@@H]1C(O)=O |r,wU:32.35,21.27,wD:34.39,(-1.73,1.79,;-3.21,1.4,;-4.3,2.48,;-5.79,2.09,;-6.88,3.17,;-8.37,2.78,;-9.46,3.87,;-10.94,3.47,;-12.03,4.56,;-11.34,1.98,;-10.94,5.01,;-6.19,.6,;-5.1,-.49,;-5.5,-1.98,;-3.61,-.09,;-2.52,-1.18,;-3.15,-2.59,;-2.24,-3.83,;-.71,-3.67,;.06,-5.01,;-.09,-2.27,;1.38,-1.79,;1.38,-.25,;-.09,.23,;-.99,-1.02,;2.7,-2.56,;4.03,-1.79,;5.36,-2.56,;6.7,-1.79,;6.7,-.25,;5.36,.52,;4.03,-.25,;8.03,.52,;9.37,1.29,;9.37,-.25,;10.7,.52,;12.03,-.25,;10.7,2.06,)|
Structure:
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