Reaction Details Report a problem with these data
Target
SRSF protein kinase 1
Ligand
BDBM448706
Substrate
n/a
Meas. Tech.
Inhibition Assay
IC50
83.1±n/a nM
Citation
 Bates, D; Morris, J; Toop, H; Batson, J; Morley, AD Compounds US Patent  US10696661 Publication Date 6/30/2020 
Target
Name:
SRSF protein kinase 1
Synonyms:
SRPK1 | SRPK1_HUMAN | SRSF protein kinase 1 (SRPK1) | Serine/arginine-protein kinase 1 (SRPK1) | Serine/threonine-protein kinase SRPK1
Type:
Protein
Mol. Mass.:
74318.38
Organism:
Homo sapiens (Human)
Description:
Q96SB4
Residue:
655
Sequence:
MERKVLALQARKKRTKAKKDKAQRKSETQHRGSAPHSESDLPEQEEEILGSDDDEQEDPNDYCKGGYHLVKIGDLFNGRYHVIRKLGWGHFSTVWLSWDIQGKKFVAMKVVKSAEHYTETALDEIRLLKSVRNSDPNDPNREMVVQLLDDFKISGVNGTHICMVFEVLGHHLLKWIIKSNYQGLPLPCVKKIIQQVLQGLDYLHTKCRIIHTDIKPENILLSVNEQYIRRLAAEATEWQRSGAPPPSGSAVSTAPQPKPADKMSKNKKKKLKKKQKRQAELLEKRMQEIEEMEKESGPGQKRPNKQEESESPVERPLKENPPNKMTQEKLEESSTIGQDQTLMERDTEGGAAEINCNGVIEVINYTQNSNNETLRHKEDLHNANDCDVQNLNQESSFLSSQNGDSSTSQETDSCTPITSEVSDTMVCQSSSTVGQSFSEQHISQLQESIRAEIPCEDEQEQEHNGPLDNKGKSTAGNFLVNPLEPKNAEKLKVKIADLGNACWVHKHFTEDIQTRQYRSLEVLIGSGYNTPADIWSTACMAFELATGDYLFEPHSGEEYTRDEDHIALIIELLGKVPRKLIVAGKYSKEFFTKKGDLKHITKLKPWGLFEVLVEKYEWSQEEAAGFTDFLLPMLELIPEKRATAAECLRHPWLNS
  
Inhibitor
Name:
BDBM448706
Synonyms:
N-(2-(4-(oxazol-4-ylmethyl)piperazin-1-yl)-5-(trifluoro- methyl)phenyl)-1H-pyrazole-3-carboxamide | US10696661, Compound 53
Type:
Small organic molecule
Emp. Form.:
C19H19F3N6O2
Mol. Mass.:
420.3884
SMILES:
FC(F)(F)c1ccc(N2CCN(Cc3cocn3)CC2)c(NC(=O)c2cc[nH]n2)c1
Structure:
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