Reaction Details Report a problem with these data
Target
Nicotinamide phosphoribosyltransferase
Ligand
BDBM50438962
Substrate
n/a
Meas. Tech.
Enzymatic Reaction Assay
IC50
3.50±n/a nM
Citation
 Bair, KW; Baumeister, TR; Buckmelter, AJ; Clodfelter, KH; Dragovich, P; Gosselin, F; Gunzner-Toste, J; Han, B; Lin, J; Liu, X; Reynolds, DJ; Smith, CC; Wang, Z; Zak, M; Zhang, Y; Zhao, G; Zheng, X; Yuen, P Amido-benzyl sulfone and sulfoxide derivates US Patent  US10696692 Publication Date 6/30/2020 
Target
Name:
Nicotinamide phosphoribosyltransferase
Synonyms:
NAMPT | NAMPT_HUMAN | NAmPRTase | Nicotinamide phosphoribosyltransferase | Nicotinamide phosphoribosyltransferase (NAMPT) | PBEF | PBEF1 | Pre-B-cell colony-enhancing factor 1
Type:
Enzyme
Mol. Mass.:
55524.98
Organism:
Homo sapiens (Human)
Description:
P43490
Residue:
491
Sequence:
MNPAAEAEFNILLATDSYKVTHYKQYPPNTSKVYSYFECREKKTENSKLRKVKYEETVFYGLQYILNKYLKGKVVTKEKIQEAKDVYKEHFQDDVFNEKGWNYILEKYDGHLPIEIKAVPEGFVIPRGNVLFTVENTDPECYWLTNWIETILVQSWYPITVATNSREQKKILAKYLLETSGNLDGLEYKLHDFGYRGVSSQETAGIGASAHLVNFKGTDTVAGLALIKKYYGTKDPVPGYSVPAAEHSTITAWGKDHEKDAFEHIVTQFSSVPVSVVSDSYDIYNACEKIWGEDLRHLIVSRSTQAPLIIRPDSGNPLDTVLKVLEILGKKFPVTENSKGYKLLPPYLRVIQGDGVDINTLQEIVEGMKQKMWSIENIAFGSGGGLLQKLTRDLLNCSFKCSYVVTNGLGINVFKDPVADPNKRSKKGRLSLHRTPAGNFVTLEEGKGDLEEYGQDLLHTVFKNGKVTKSYSFDEIRKNAQLNIELEAAHH
  
Inhibitor
Name:
BDBM50438962
Synonyms:
CHEMBL2420637 | US10696692, Example 6
Type:
Small organic molecule
Emp. Form.:
C19H21N5O3S
Mol. Mass.:
399.467
SMILES:
O=C(NCc1ccc(cc1)S(=O)(=O)N1CCCCC1)c1cnc2nccn2c1
Structure:
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