Reaction Details Report a problem with these data
Target
Nicotinamide phosphoribosyltransferase
Ligand
BDBM449127
Substrate
n/a
Meas. Tech.
Enzymatic Reaction Assay
IC50
6.80±n/a nM
Citation
 Bair, KW; Baumeister, TR; Buckmelter, AJ; Clodfelter, KH; Dragovich, P; Gosselin, F; Gunzner-Toste, J; Han, B; Lin, J; Liu, X; Reynolds, DJ; Smith, CC; Wang, Z; Zak, M; Zhang, Y; Zhao, G; Zheng, X; Yuen, P Amido-benzyl sulfone and sulfoxide derivates US Patent  US10696692 Publication Date 6/30/2020 
Target
Name:
Nicotinamide phosphoribosyltransferase
Synonyms:
NAMPT | NAMPT_HUMAN | NAmPRTase | Nicotinamide phosphoribosyltransferase | Nicotinamide phosphoribosyltransferase (NAMPT) | PBEF | PBEF1 | Pre-B-cell colony-enhancing factor 1
Type:
Enzyme
Mol. Mass.:
55524.98
Organism:
Homo sapiens (Human)
Description:
P43490
Residue:
491
Sequence:
MNPAAEAEFNILLATDSYKVTHYKQYPPNTSKVYSYFECREKKTENSKLRKVKYEETVFYGLQYILNKYLKGKVVTKEKIQEAKDVYKEHFQDDVFNEKGWNYILEKYDGHLPIEIKAVPEGFVIPRGNVLFTVENTDPECYWLTNWIETILVQSWYPITVATNSREQKKILAKYLLETSGNLDGLEYKLHDFGYRGVSSQETAGIGASAHLVNFKGTDTVAGLALIKKYYGTKDPVPGYSVPAAEHSTITAWGKDHEKDAFEHIVTQFSSVPVSVVSDSYDIYNACEKIWGEDLRHLIVSRSTQAPLIIRPDSGNPLDTVLKVLEILGKKFPVTENSKGYKLLPPYLRVIQGDGVDINTLQEIVEGMKQKMWSIENIAFGSGGGLLQKLTRDLLNCSFKCSYVVTNGLGINVFKDPVADPNKRSKKGRLSLHRTPAGNFVTLEEGKGDLEEYGQDLLHTVFKNGKVTKSYSFDEIRKNAQLNIELEAAHH
  
Inhibitor
Name:
BDBM449127
Synonyms:
Imidazo[1,2-a]pyridine-6-carboxylic acid 4-[4-(2- dimethylamino-ethyl)- piperazine-1-sulfonyl]- benzylamide | US10696692, Example 105
Type:
Small organic molecule
Emp. Form.:
C23H30N6O3S
Mol. Mass.:
470.588
SMILES:
CN(C)CCN1CCN(CC1)S(=O)(=O)c1ccc(CNC(=O)c2ccc3nccn3c2)cc1
Structure:
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