Reaction Details Report a problem with these data
Target
Nicotinamide phosphoribosyltransferase
Ligand
BDBM449265
Substrate
n/a
Meas. Tech.
Enzymatic Reaction Assay
IC50
7.03±n/a nM
Citation
Bair, KW; Baumeister, TR; Buckmelter, AJ; Clodfelter, KH; Dragovich, P; Gosselin, F; Gunzner-Toste, J; Han, B; Lin, J; Liu, X; Reynolds, DJ; Smith, CC; Wang, Z; Zak, M; Zhang, Y; Zhao, G; Zheng, X; Yuen, P Amido-benzyl sulfone and sulfoxide derivates US Patent US10696692 Publication Date 6/30/2020
More Info.:
Target
Name:
Nicotinamide phosphoribosyltransferase
Synonyms:
NAMPT | NAMPT_HUMAN | NAmPRTase | Nicotinamide phosphoribosyltransferase | Nicotinamide phosphoribosyltransferase (NAMPT) | PBEF | PBEF1 | Pre-B-cell colony-enhancing factor 1
Type:
Enzyme
Mol. Mass.:
55524.98
Organism:
Homo sapiens (Human)
Description:
P43490
Residue:
491
Sequence:
MNPAAEAEFNILLATDSYKVTHYKQYPPNTSKVYSYFECREKKTENSKLRKVKYEETVFYGLQYILNKYLKGKVVTKEKIQEAKDVYKEHFQDDVFNEKGWNYILEKYDGHLPIEIKAVPEGFVIPRGNVLFTVENTDPECYWLTNWIETILVQSWYPITVATNSREQKKILAKYLLETSGNLDGLEYKLHDFGYRGVSSQETAGIGASAHLVNFKGTDTVAGLALIKKYYGTKDPVPGYSVPAAEHSTITAWGKDHEKDAFEHIVTQFSSVPVSVVSDSYDIYNACEKIWGEDLRHLIVSRSTQAPLIIRPDSGNPLDTVLKVLEILGKKFPVTENSKGYKLLPPYLRVIQGDGVDINTLQEIVEGMKQKMWSIENIAFGSGGGLLQKLTRDLLNCSFKCSYVVTNGLGINVFKDPVADPNKRSKKGRLSLHRTPAGNFVTLEEGKGDLEEYGQDLLHTVFKNGKVTKSYSFDEIRKNAQLNIELEAAHH
Inhibitor
Name:
BDBM449265
Synonyms:
N-[[4-[3-(4-methylpiperazine- 1-carbonyl)azetidin-1- yl]sulfonylphenyl]methyl] imidazo[1,2-a]pyridine-6- carboxamide | US10696692, Example 246
Type:
Small organic molecule
Emp. Form.:
C24H28N6O4S
Mol. Mass.:
496.582
SMILES:
CN1CCN(CC1)C(=O)C1CN(C1)S(=O)(=O)c1ccc(CNC(=O)c2ccc3nccn3c2)cc1